NCF4 Products

Description

The NADPH oxidase generates superoxide in phagocytic cells. It is important for immunity and its deficiency leads to chronic granulomatous disease (CGD) (1). p40-phox is a newly isolated cytosolic component of the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase that copurifies with p67-phox. Preliminary evidence indicates that it is a component of the cytosolic complex (2). Maximal activation of NADPH oxidase requires formation of a complex between the p40-phox and p67-phox subunits via association of their PB1 domains. The crystal structure of the p40-phox/p67phox PB1 heterodimer reveals that both domains have a beta grasp topology and that they bind in a front-to-back arrangement through conserved electrostatic interactions between an acidic OPCA motif on p40-phox and basic residues in p67-phox (3).

Bioinformatics

Uniprot	A8K4F9 Human AAH02798 Human NM_013416 Human NP_000622 Human NP_000622.2 Human Q15080 Human
Product By Gene ID	4689
Alternate Names	MGC3810 NCF NCF-4 neutrophil cytosol factor 4 neutrophil cytosolic factor 4 (40kD) neutrophil cytosolic factor 4, 40kDa Neutrophil NADPH oxidase factor 4 p40phox p40-phox SH3 and PX domain-containing protein 4 SH3PXD4P40PHOX

Research Areas for NCF4

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Signal Transduction