NCF4 Products

Antibodies
NCF4 Antibody
NCF4 Antibody
NB100-61666
Species: Hu
Applications: WB, IHC, IHC-P, PEP-ELISA
Host: Goat Polyclonal
NCF4 Antibody (4B5)
NCF4 Antibody (4B5)
NBP2-46111
Species: Hu
Applications: WB, IHC
Host: Mouse monoclonal
NCF4 Antibody
NCF4 Antibody
H00004689-D01P
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
Lysates
NCF4 Overexpression Lysate (D ...
NCF4 Overexpression Lysate (Denatu...
H00004689-T01
Species: Hu
Applications: WB
NCF4 Overexpression Lysate (N ...
NCF4 Overexpression Lysate (Native)
NBL1-13511
Applications: WB
NCF4 Overexpression Lysate (N ...
NCF4 Overexpression Lysate (Native)
NBP2-09005
Applications: WB
Proteins
NCF4 Recombinant Protein Anti ...
NCF4 Recombinant Protein Antigen
NBP2-32720PEP
Species: Hu
Applications: AC
NCF4 Recombinant Protein
NCF4 Recombinant Protein
NBP2-23284
Species: Hu
Applications: PAGE
RNAi
NCF4 RNAi
NCF4 RNAi
H00004689-R02
Species: Hu
Applications: RNAi, RNAi SP
NCF4 RNAi
NCF4 RNAi
H00004689-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The NADPH oxidase generates superoxide in phagocytic cells. It is important for immunity and its deficiency leads to chronic granulomatous disease (CGD) (1). p40-phox is a newly isolated cytosolic component of the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase that copurifies with p67-phox. Preliminary evidence indicates that it is a component of the cytosolic complex (2). Maximal activation of NADPH oxidase requires formation of a complex between the p40-phox and p67-phox subunits via association of their PB1 domains. The crystal structure of the p40-phox/p67phox PB1 heterodimer reveals that both domains have a beta grasp topology and that they bind in a front-to-back arrangement through conserved electrostatic interactions between an acidic OPCA motif on p40-phox and basic residues in p67-phox (3).

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 4689
Alternate Names
  • neutrophil cytosol factor 4
  • p40-phox
  • NCF
  • NCF-4
  • MGC3810
  • Neutrophil NADPH oxidase factor 4
  • neutrophil cytosolic factor 4 (40kD)
  • p40phox
  • SH3PXD4P40PHOX
  • SH3 and PX domain-containing protein 4
  • neutrophil cytosolic factor 4, 40kDa

Research Areas for NCF4

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction

PTMs for NCF4

Learn more about PTMs related to NCF4.

Phosphorylation

Bioinformatics Tool for NCF4

Discover related pathways, diseases and genes to NCF4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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