Species: Hu
Applications: WB, ICC/IF, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ELISA, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated (Smad2 and 3) or BMP receptor regulated (Smad 1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smads; and the inhibitory Smads, (Smad6 and 7). Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. Phosphorylation of the two TGF beta dependent serines 423 and 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity and TGF beta signaling.
Bioinformatics
Uniprot |
Human Human Human |
Product By Gene ID |
23310 |
Alternate Names |
- CAPD3
- CAP-D3
- FLJ42888
- hCAP-D3condensin-2 complex subunit D3
- hcp-6
- hHCP-6
- KIAA0056MGC104671
- Non-SMC condensin II complex subunit D3
- non-SMC condensin II complex, subunit D3
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Research Areas for NCAPD3
Find related products by research area and learn more about each of the different research areas below.
DNA Repair