WB, ICC/IF, IPHost:
Applications: WB, ELISA, IHC, IHC-P
Host: Mouse Monoclonal
Host: Rabbit Polyclonal
Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated (Smad2 and 3) or BMP receptor regulated (Smad 1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smads; and the inhibitory Smads, (Smad6 and 7). Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. Phosphorylation of the two TGF beta dependent serines 423 and 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity and TGF beta signaling.
|Product By Gene ID
- Non-SMC condensin II complex subunit D3
- hCAP-D3condensin-2 complex subunit D3
- non-SMC condensin II complex, subunit D3
Research Areas for NCAPD3
Find related products by research area and learn more about each of the different research areas below.DNA Repair
PTMs for NCAPD3
Learn more about PTMs related to NCAPD3.Demethylation
Bioinformatics Tool for NCAPD3
Discover related pathways, diseases and genes to NCAPD3. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.