NCAPD3 Products

Description

Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated (Smad2 and 3) or BMP receptor regulated (Smad 1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smads; and the inhibitory Smads, (Smad6 and 7). Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. Phosphorylation of the two TGF beta dependent serines 423 and 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity and TGF beta signaling.

Bioinformatics

Uniprot	AAH11408 Human NP_056076 Human P42695 Human
Product By Gene ID	23310
Alternate Names	CAPD3 CAP-D3 FLJ42888 hCAP-D3condensin-2 complex subunit D3 hcp-6 hHCP-6 KIAA0056MGC104671 Non-SMC condensin II complex subunit D3 non-SMC condensin II complex, subunit D3

Research Areas for NCAPD3

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DNA Repair