NCAPD3 Products

Description

Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated (Smad2 and 3) or BMP receptor regulated (Smad 1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smads; and the inhibitory Smads, (Smad6 and 7). Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. Phosphorylation of the two TGF beta dependent serines 423 and 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity and TGF beta signaling.

Bioinformatics

Uniprot	P42695 Human AAH11408 Human NP_056076 Human
Product By Gene ID	23310
Alternate Names	hHCP-6 Non-SMC condensin II complex subunit D3 FLJ42888 CAPD3 CAP-D3 hCAP-D3condensin-2 complex subunit D3 KIAA0056MGC104671 hcp-6 non-SMC condensin II complex, subunit D3

Diseases related to NCAPD3

Discover more about diseases related to NCAPD3.

Growth Retardation
Haploinsufficiency
Congenital Anomaly Of Face
Microcephaly
Heart Diseases
Congenital Heart Disease
Jacobsen Distal 11q Deletion Syndrome
Developmental Delay (disorder)
Craniofacial Abnormalities
Developmental Disabilities

Pathways for NCAPD3

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Cell Cycle
Prophase
Mitosis
Demethylation

Research Areas for NCAPD3

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DNA Repair

PTMs for NCAPD3

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Demethylation

Bioinformatics Tool for NCAPD3

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