N-Acetylmannosamine Kinase/GNE Products

Antibodies
N-Acetylmannosamine Kinase/GN ...
N-Acetylmannosamine Kinase/GNE Ant...
NBP1-81621
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
N-Acetylmannosamine Kinase/GN ...
N-Acetylmannosamine Kinase/GNE Ant...
NBP1-81622
Species: Hu, Mouse, Rat
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
N-Acetylmannosamine Kinase/GN ...
N-Acetylmannosamine Kinase/GNE Ant...
H00010020-D01P
Species: Hu
Applications: WB, ELISA
Host: Rabbit Polyclonal
Lysates
N-Acetylmannosamine Kinase/GN ...
N-Acetylmannosamine Kinase/GNE Ove...
NBP2-07744
Applications: WB
N-Acetylmannosamine Kinase/GN ...
N-Acetylmannosamine Kinase/GNE Ove...
H00010020-T01
Species: Hu
Applications: WB
Proteins
N-Acetylmannosamine Kinase/GN ...
N-Acetylmannosamine Kinase/GNE Par...
H00010020-Q01
Species: Hu
Applications: WB, ELISA, PA
N-Acetylmannosamine Kinase/GN ...
N-Acetylmannosamine Kinase/GNE Rec...
NBP1-81621PEP
Species: Hu
Applications: AC
N-Acetylmannosamine Kinase/GN ...
N-Acetylmannosamine Kinase/GNE Rec...
NBP1-81622PEP
Species: Hu
Applications: AC
RNAi
N-Acetylmannosamine Kinase/GN ...
N-Acetylmannosamine Kinase/GNE RNAi
H00010020-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

The protein encoded by the GNE gene is a bifunctional enzyme that monitors and begins biosynthesis of N-acetylneuraminic acid (NeuAc). NeuAC is a precursor of sialic acids and functions in early development as sialylation is a component of cell adhesion, signal transduction, and tumorigencity and metastic behavior of malignant cells. The GNE gene has been linked to various diseases such as: myopathy, dementia, glomerulosclerosis, muscular dystrophy, and neuromuscular disease. This protein creates an enzyme that is rate-limiting in the sialic acid biosynthetic pathway as well as plays a role in amino and nucleotide sugar metabolism as well as CMP-N-acetylneuraminate biosynthesis in eukaryotes. The GNE gene is known to interact with genes CRMP1. ZBTB16, PIK3C2A, KIAA1549, and RIF1 to participate in these pathways. GNE exists is five isoforms: isoform 1: 722 amino acids long; 79 kDA; isoform 2: 753 amino acids long, 83 kDA; isoform 3: 681 amino acids long; 74 kDA; isoform 4: 648 amino acids long, 71 kDA; isoform 5: 612 amino acids long, 66 kDA.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 10020
Alternate Names
  • DMRV
  • UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
  • UDP-GlcNAc-2-epimerase/ManAc kinase
  • N-acylmannosamine kinase
  • UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
  • bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
  • Uae1
  • GLCNENM
  • IBM2
  • glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

PTMs for N-Acetylmannosamine Kinase/GNE

Learn more about PTMs related to N-Acetylmannosamine Kinase/GNE.

Phosphorylation
Glycosylation
Demethylation
Nitrosylation
Biotinylation
Deacetylation
Acetylation
Methylation

Bioinformatics Tool for N-Acetylmannosamine Kinase/GNE

Discover related pathways, diseases and genes to N-Acetylmannosamine Kinase/GNE. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.