MYOM1 Products

Description

The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Bioinformatics

Uniprot	P52179 Human
Product By Gene ID	8736
Alternate Names	myomesin-1 190 kDa titin-associated protein myomesin (M-protein) 1 (190kD) 190 kDa connectin-associated protein SKELEMIN Myomesin family member 1 MGC134947 myomesin 1 (skelemin) 185kDa MGC134946 myomesin 1 (skelemin) (185kD) EH-myomesin myomesin 1, 185kDa

Diseases related to MYOM1

Discover more about diseases related to MYOM1.

Tissue Adhesions
Dystrophy
Thrombosis
Periodontitis
Hepatitis B
Malignant Neoplasm Of Liver
Periodontitis, Juvenile
Organic Writer's Cramp
Carcinoma
Congenital Heart Defects
Malignant Neoplasms
Rheumatoid Arthritis
Myotonic Dystrophy
Chronic Arthritis
Arthritis, Juvenile Rheumatoid
Severe Myopia
Liver Carcinoma
Hepatitis
Dystonia Disorders

Pathways for MYOM1

View related products by pathway and learn more about each of the pathways below.

Cell Adhesion
Cellular Response To Dsrna
Response To Dsrna
Localization
Sarcomerogenesis
T Cell Differentiation
Erbb Signaling Pathway
Reverse Transcription
Coagulation
Cell Death
Cell Differentiation
Dsrna Fragmentation
Catabolic Process
Hemostasis
Ncrna Catabolic Process
Chromatin Remodeling

Bioinformatics Tool for MYOM1

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