MUC12 Products

Antibodies
MUC12 Antibody
MUC12 Antibody
NB200-124
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-P, IP, RIA
Host: Rabbit Polyclonal
MUC12 Antibody
MUC12 Antibody
NB200-125
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
MUC12 Antibody
MUC12 Antibody
NBP1-82607
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Proteins
MUC12 Partial Recombinant Pro ...
MUC12 Partial Recombinant Protein
H00010071-Q02
Species: Hu
Applications: WB, ELISA, PA
MUC12 Partial Recombinant Pro ...
MUC12 Partial Recombinant Protein
H00010071-Q01
Species: Hu
Applications: WB, ELISA, PA
MUC12 Recombinant Protein Ant ...
MUC12 Recombinant Protein Antigen
NBP1-82607PEP
Species: Hu
Applications: AC

Description

Human MUC12 (Mucin 12) is a novel mucin of epithelial mucins, which are large, secreted or cell surface glycoproteins involved in epithelial cell protection, adhesion modulation, and signaling. Using differential display on RNA from paired normal colonic mucosa and primary colorectal tumor, MUC12 is identified as one of the 2 partial cDNAs representing novel mucin genes as well as MUC11. They are downregulated in colorectal tumors.The deduced MUC12 protein contains a predicted transmembrane domain, 2 extracellular cysteine-rich EGF-like domains, a coiled-coil region, and a domain consisting of serine-, threonine-, and proline-rich degenerate tandem repeats of 28 amino acids, a structural feature typical of mucins. Human MUC12 shares high sequence homology with MUC3 and MUC4. Northern blot analysis of 50 different normal tissues detected MUC12 expression in colon, pancreas, prostate, and uterus, with highest expression in colon. The MUC12 transcript is large, estimated to be longer than 12 kb. Expression of MUC12 was downregulated or absent in 6 of 15 (40%) colorectal tumors, as compared with matched normal colonic tissues. MUC12 expression was not detected in any of 6 colorectal cancer cell lines examined. Epitheial mucins are secreted glycoproteins that play roles in cell protection, adhesion modulation and signaling. MUC 12 is a novel mucin gene and may be involved in epithelial cell growth regulation. MUC 12 is down-regulated in colorectal cancers.

Bioinformatics

Entrez Human
Product By Gene ID 10071
Alternate Names
  • MUC11
  • MUC-11
  • MUC-12
  • mucin 11
  • mucin-12
  • mucin-11
  • mucin 12, cell surface associated

Pathways for MUC12

View related products by pathway and learn more about each of the pathways below.

Transport
Reverse Transcription
Exocytosis
Secretion
Sulfation
Cell Adhesion
Glycosylation
Cell Growth
Pathogenesis

Research Areas for MUC12

Find related products by research area and learn more about each of the different research areas below.

Cancer
Tumor Suppressors

PTMs for MUC12

Learn more about PTMs related to MUC12.

Cleavage
Glycosylation
Phosphorylation

Bioinformatics Tool for MUC12

Discover related pathways, diseases and genes to MUC12. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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