MTH1 Products

Description

Oxygen radicals damage chromosomal DNA causing cell death and inducing mutations. Among the various classes of DNA damage caused by oxygen radicals, an oxidized form of guanine base (8-oxoguanine) appears to be important as it can pair with cytosine and adenine and G:C to T:A transversion mutation occurs. A significant amount of 8-OxoG is formed in the chromosomal DNA of mammalian cells, with most damaged nucleotides excised from the DNA and excreted in the urine. Along with 8-oxoG being present in oxidatively damaged DNA, 8-oxo-deoxyguanosine (8-oxo-dGTP) is formed in the nucleotide pool during normal cellular metabolism and following oxidative stress. The 8-oxo-dGTP nucleotide can be incorporated in DNA during polymerization and can result in a mispairing unless repaired. MTH converts 8-oxo-dGTP in the nucleotide pool to the monophosphate and prevents the misincorporation of 8-oxo-dGTP into DNA (Figure courtesy of Dr. Mark Kelley). MTH also recognizes 8-oxo-rGTP, which could incorporate into RNA during gene transcription leading to missense or nonsense protein production.

Bioinformatics

Entrez	117260 Rat 17766 Mouse 4521 Human
Uniprot	AAH14618 Human NM_002452 Human NM_198952 Human NP_002443 Human NP_002443.3 Human NP_945186 Human NP_945187 Human NP_945188 Human NP_945191 Human NP_945192 Human P36639 Human
Product By Gene ID	4521
Alternate Names	8-oxo-7,8-dihydrodeoxyguanosine triphosphatase EC 3.6.1.- MTH1Nucleoside diphosphate-linked moiety X motif 1 mutT human homolog 1,8-oxo-dGTPase nucleoside diphosphate-linked moiety X-type motif 17,8-dihydro-8-oxoguanine triphosphatase nudix (nucleoside diphosphate linked moiety X)-type motif 1,8-oxo-7,8-dihydroguanosine triphosphatase Nudix motif 1

Research Areas for MTH1

Find related products by research area and learn more about each of the different research areas below.

Base Excision Repair
Cancer
Chromatin Research
DNA Repair
Modulation of DNA Pools
Stem Cell Markers

Related MTH1 Blog Posts

Check out the latest blog posts on MTH1.

MTH1: Effects on DNA Damage Repair, Cancer and Neurodegeneration MTH1 (human MutT Homolog 1) is a purine nucleoside triphosphatase enzyme and belongs to the Nudix hydrolase family. In mammalian systems, MTH is a major detoxifier of the oxidized DNA precursors, 8-oxo-dGTP, 8-oxo-dATP, and 2-OH-dATP and prevents the ...    Read more.

Read more MTH1 related blogs.