MTH1 Products

Antibodies
MTH1 Antibody
MTH1 Antibody
NB100-109
Species: Hu, Mu, Rt
Applications: WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P
Host: Rabbit Polyclonal
MTH1 Antibody
MTH1 Antibody
H00004521-D01P
Species: Hu
Applications: WB, ELISA
Host: Rabbit Polyclonal
MTH1 Antibody (5F11)
MTH1 Antibody (5F11)
H00004521-M02
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Antibody Pairs
MTH1 Antibody Pair
MTH1 Antibody Pair
H00004521-PW1
Species: Hu
Applications: WB, IP
MTH1 Antibody Pair
MTH1 Antibody Pair
H00004521-AP11
Species: Hu
Applications: S-ELISA
Lysates
MTH1 Overexpression Lysate (D ...
MTH1 Overexpression Lysate (Denatu...
H00004521-T01
Species: Hu
Applications: WB
MTH1 Overexpression Lysate (N ...
MTH1 Overexpression Lysate (Native)
NBP2-04633
Applications: WB
MTH1 Overexpression Lysate (N ...
MTH1 Overexpression Lysate (Native)
NBP2-04636
Applications: WB
Proteins
MTH1 Recombinant Protein
MTH1 Recombinant Protein
NBP1-49309
Species: Hu
Applications: PAGE
RNAi
MTH1 RNAi
MTH1 RNAi
H00004521-R05
Species: Hu
MTH1 RNAi
MTH1 RNAi
H00004521-R02
Species: Hu
MTH1 RNAi
MTH1 RNAi
H00004521-R03
Species: Hu

Description

Oxygen radicals damage chromosomal DNA causing cell death and inducing mutations. Among the various classes of DNA damage caused by oxygen radicals, an oxidized form of guanine base (8-oxoguanine) appears to be important as it can pair with cytosine and adenine and G:C to T:A transversion mutation occurs. A significant amount of 8-OxoG is formed in the chromosomal DNA of mammalian cells, with most damaged nucleotides excised from the DNA and excreted in the urine. Along with 8-oxoG being present in oxidatively damaged DNA, 8-oxo-deoxyguanosine (8-oxo-dGTP) is formed in the nucleotide pool during normal cellular metabolism and following oxidative stress. The 8-oxo-dGTP nucleotide can be incorporated in DNA during polymerization and can result in a mispairing unless repaired. MTH converts 8-oxo-dGTP in the nucleotide pool to the monophosphate and prevents the misincorporation of 8-oxo-dGTP into DNA (Figure courtesy of Dr. Mark Kelley). MTH also recognizes 8-oxo-rGTP, which could incorporate into RNA during gene transcription leading to missense or nonsense protein production.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 4521
Alternate Names
  • 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase
  • EC 3.6.1.-
  • nucleoside diphosphate-linked moiety X-type motif 17,8-dihydro-8-oxoguanine triphosphatase
  • mutT human homolog 1,8-oxo-dGTPase
  • Nudix motif 1
  • MTH1Nucleoside diphosphate-linked moiety X motif 1
  • nudix (nucleoside diphosphate linked moiety X)-type motif 1,8-oxo-7,8-dihydroguanosine triphosphatase

Research Areas for MTH1

Find related products by research area and learn more about each of the different research areas below.

Base Excision Repair
Cancer
Chromatin Research
DNA Repair
Modulation of DNA Pools
Stem Cell Markers

PTMs for MTH1

Learn more about PTMs related to MTH1.

Cleavage
Oxidation

Bioinformatics Tool for MTH1

Discover related pathways, diseases and genes to MTH1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related MTH1 Blog Posts

Check out the latest blog posts on MTH1.
MTH1: Effects on DNA Damage Repair, Cancer and Neurodegeneration
MTH1 (human MutT Homolog 1) is a purine nucleoside triphosphatase enzyme and belongs to the Nudix hydrolase family. In mammalian systems, MTH is a major detoxifier of the oxidized DNA precursors, 8-oxo-dGTP, 8-oxo-dATP, and 2-OH-dATP and prevents the...    Read more.
Read more MTH1 related blogs.