MST2/STK3 Products

Antibodies
MST2/STK3 Antibody (2072A) [U ...
MST2/STK3 Antibody (2072A) [Unconj...
MAB4549
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, ICC
Host: Rabbit Monoclonal
MST2/STK3 Antibody (4G10)
MST2/STK3 Antibody (4G10)
Species: Hu, Mu, Rt, Ca, Mk
Applications: WB, IHC, IHC-P
Host: Mouse Monoclonal
MST2/STK3 Antibody
MST2/STK3 Antibody
NBP1-32313
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
MST2/STK3 Overexpression Lysa ...
MST2/STK3 Overexpression Lysate (D...
H00006788-T01
Species: Hu
Applications: WB
MST2/STK3 Overexpression Lysa ...
MST2/STK3 Overexpression Lysate (N...
NBL1-16546
Applications: WB
Proteins
MST2/STK3 Recombinant Protein ...
MST2/STK3 Recombinant Protein Antigen
NBP1-89586PEP
Species: Hu
Applications: AC
Recombinant Human MST2/STK3 P ...
Recombinant Human MST2/STK3 Protein
NBP2-53049
Species: Hu
Applications: PAGE
Recombinant Human MST2/STK3 P ...
Recombinant Human MST2/STK3 Protein
P4727
Species: Hu
Applications: Func, PAGE
RNAi
MST2/STK3 RNAi
MST2/STK3 RNAi
H00006788-R03
Species: Hu
Applications: RNAi, RNAi SP

Description

Mammalian Sterile 20-Like 2 (Mst2) is most similar to the previously identified Mst1 protein kinase (78% identity, 88% similarity). Northern analysis indicates that MST2 mRNA is expressed at high levels in adult kidney, skeletal and placental tissues and at very low levels in adult heart, lung, liver and brain tissues. An in-vitro kinase assay indicates that Mst2 can phosphorylate an exogenous substrate, as well as itself, and phospho-amino-acid analysis indicates that it is a serine/threonine protein kinase (1) Mst2, a STE20-family member and purported Hpo ortholog, phosphorylates and activates both Lats1 and Lats2. Results indicate that Mst2-like kinases regulate Lats kinase activities in an evolutionarily conserved regulatory pathway (2). When stably expressed in HeLa cells, Mst highly sensitizes the cells to death receptor-mediated apoptosis by accelerating caspase-3 activation. These findings suggest that Mst1 and Mst2 play a role in apoptosis both upstream and downstream of caspase activation (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 6788
Alternate Names
  • MST-2
  • EC 2.7.11
  • Serine/threonine-protein kinase Krs-1
  • serine/threonine-protein kinase 3
  • Mammalian STE20-like protein kinase 2
  • serine/threonine kinase 3 (STE20 homolog, yeast)
  • serine/threonine kinase 3 (Ste20, yeast homolog)
  • FLJ90748
  • KRS1
  • MST2EC 2.7.11.1
  • STE20-like kinase MST2
  • serine/threonine kinase 3

Research Areas for MST2/STK3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis

PTMs for MST2/STK3

Learn more about PTMs related to MST2/STK3.

Phosphorylation
Cleavage
Methylation
Dephosphorylation
Reduction
Geranylgeranylation
Myristoylation

Bioinformatics Tool for MST2/STK3

Discover related pathways, diseases and genes to MST2/STK3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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