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MRPL3, also known as 39 S ribosomal protein L3, mitochondrial, is a 38.6 kDa, 348 amino acid protein that, when defected, causes a mitochondrial disease that results poor health, mental retardation, and, in some cases, death in infancy. Current research is observing the effects of the protein on diseases and disorders such as pneumonia, cardiomyopathy, mycobacterium tuberculosis, and malaria. The protein interacts with other proteins such as PUS1, DAP3, ICT1, MRPL13, and MRPL2.