MORF4L2 Products

Antibodies
MORF4L2 Antibody
MORF4L2 Antibody
NBP2-47370
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
MORF4L2 Antibody
MORF4L2 Antibody
NBP2-58131
Species: Hu, Rt
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
MORF4L2 Antibody
MORF4L2 Antibody
NB300-803
Species: Hu
Applications: WB, PEP-ELISA
Host: Goat Polyclonal
Lysates
MORF4L2 Overexpression Lysate ...
MORF4L2 Overexpression Lysate (Nat...
NBL1-13184
Applications: WB
Proteins
MORF4L2 Recombinant Protein A ...
MORF4L2 Recombinant Protein Antigen
NBP2-47370PEP
Species: Hu
Applications: AC
MORF4L2 Recombinant Protein A ...
MORF4L2 Recombinant Protein Antigen
NBP2-58131PEP
Species: Hu
Applications: AC
Recombinant Human MORF4L2 Pro ...
Recombinant Human MORF4L2 Protein
NBP1-51057
Species: Hu
Applications: PAGE

Description

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit HTATIP/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP and YEATS4/GAS41. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the HTATIP/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the MSIN3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. MORF4L1 interacts with RB1 and MYST1. MORF4L1 may also interact with PHF12 and one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors. MRGX plays a role in growth regulation and replicative senescence. Expression of MRGX, which initially increases during cell cycle, may have to decrease for cells to enter the S phase.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Product By Gene ID 9643
Alternate Names
  • MSL3-2 protein
  • MORFL2
  • mortality factor 4-like protein 2
  • MORF-related gene X protein
  • Transcription factor-like protein MRGX
  • KIAA0026MRGXProtein MSL3-2
  • mortality factor 4 like 2

Pathways for MORF4L2

View related products by pathway and learn more about each of the pathways below.

Senescence
Cell Death
Cellular Senescence
Cell Cycle
Aging
Cell Growth
Interphase
Conjugation

PTMs for MORF4L2

Learn more about PTMs related to MORF4L2.

Ubiquitination

Bioinformatics Tool for MORF4L2

Discover related pathways, diseases and genes to MORF4L2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.