MKLP1 Products

Description

Using the CHO1 monoclonal antibody, Sellitto and Kuriyama (1988) identified a spindle antigen that was shown by Nislow et al. (1990) to be required for mitotic progression. By using the CHO1 antibody to screen a HeLa cell cDNA library, Nislow et al. (1992) isolated a KNSL5 cDNA, which they called MKLP1 (mitotic kinesin-like protein-1), that encodes this antigen. The N-terminal region of the deduced 961-amino acid protein contains a 350-residue domain that shares 30 to 45% identity with the motor domains of other members of the kinesin superfamily. The C-terminal region shows little identity with other kinesins. A central region contains heptad repeats of hydrophobic residues that may assemble into a coiled-coil structure similar to kinesin and myosin heavy chain proteins. The protein also contains a putative nuclear localization signal and 2 consensus phosphorylation sites characteristic of nuclear proteins.

Bioinformatics

Entrez	9493 Human
Uniprot	Q02241 Human Q02241-2 Human NP_004847 Human NP_004847.2 Human
Product By Gene ID	9493
Alternate Names	mitotic kinesin-like 1 kinesin-like 5 (mitotic kinesin-like protein 1) kinesin-like protein KIF23 MKLP-1 KNSL5CHO1 MKLP1Mitotic kinesin-like protein 1 Kinesin-like protein 5 kinesin family member 23

Diseases related to MKLP1

Discover more about diseases related to MKLP1.

Malignant Neoplasms
Neoplasms
Nervousness
Adenocarcinoma
Colonic Neoplasms
Malignant Tumor Of Colon
Glioma
Bone Neoplasms
Aneuploidy
Neoplasm Invasiveness
Malignant Neoplasm Of Lung
Carcinoma
Osteosarcoma
Fibrosarcoma
Lymphoma
Chimera Disorder
Riboflavin Deficiency
Cell Invasion
Malignant Neoplasm Of Prostate
Malignant Squamous Cell Neoplasm

Pathways for MKLP1

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Cytokinesis
Localization
Anaphase
Cell Division
Mitosis
Cell Cycle
Chromosome Segregation
Metaphase
Abscission
Transport
Cell Proliferation
Cell Cycle Arrest
Interphase
Telophase
Spindle Localization
M Phase
Spindle Assembly
Rna Interference
Cleavage Furrow Formation
Cell Migration

Research Areas for MKLP1

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Cell Cycle and Replication
Core ESC-Like Genes
DNA Repair
Stem Cell Markers

PTMs for MKLP1

Learn more about PTMs related to MKLP1.

Phosphorylation
Cleavage
Glycosylation
Acetylation
Dephosphorylation

Bioinformatics Tool for MKLP1

Discover related pathways, diseases and genes to MKLP1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.