MKLP1 Products

Description

Using the CHO1 monoclonal antibody, Sellitto and Kuriyama (1988) identified a spindle antigen that was shown by Nislow et al. (1990) to be required for mitotic progression. By using the CHO1 antibody to screen a HeLa cell cDNA library, Nislow et al. (1992) isolated a KNSL5 cDNA, which they called MKLP1 (mitotic kinesin-like protein-1), that encodes this antigen. The N-terminal region of the deduced 961-amino acid protein contains a 350-residue domain that shares 30 to 45% identity with the motor domains of other members of the kinesin superfamily. The C-terminal region shows little identity with other kinesins. A central region contains heptad repeats of hydrophobic residues that may assemble into a coiled-coil structure similar to kinesin and myosin heavy chain proteins. The protein also contains a putative nuclear localization signal and 2 consensus phosphorylation sites characteristic of nuclear proteins.

Bioinformatics

Entrez	9493 Human
Uniprot	NP_004847 Human NP_004847.2 Human Q02241 Human Q02241-2 Human
Product By Gene ID	9493
Alternate Names	kinesin family member 23 kinesin-like 5 (mitotic kinesin-like protein 1) Kinesin-like protein 5 kinesin-like protein KIF23 KNSL5CHO1 mitotic kinesin-like 1 MKLP-1 MKLP1Mitotic kinesin-like protein 1

Research Areas for MKLP1

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Core ESC-Like Genes
DNA Repair
Stem Cell Markers