MHC Class II RT1B Products

Description

MHC Class II antigens are heterodimers consisting of one alpha chain(31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR 3, ER-TR 2, ER-TR 1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma.

Bioinformatics

Entrez	14998 Mouse 294274 Rat
Product By Gene ID	24738
Alternate Names	anti-OX-6 RT1B anti-RT1B OX-6 Clone OX6 DMA DMB DP beta 1 DPB 1 DPB1 DRB HLA class II histocompatibility antigen DM beta chain HLA DMB HLA DPB1 HLADM HLADP1B Major histocompatibility complex class II DP beta 1 Major histocompatibility complex class II MHC class II antigen DMB MHC class II DQ MHC DPB1 Non-polymorphic MHC Class II RING6 RING7 RT1B

Research Areas for MHC Class II RT1B

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Adaptive Immunity
Immunology

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The role of MHC Class II RT1B and immune response post brain injury The major histocompatibility complex (MHC) is responsible for binding peptide fragments arising from pathogens in order to display them on the cell surface for recognition from immune cells.  Once recognized, the foreign pathogen is typically evade...    Read more.

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