MGAT4A Products

Description

MGAT4A encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.

Bioinformatics

Entrez	11320 Human
Uniprot	NP_036346 Human Q9UM21 Human
Product By Gene ID	11320
Alternate Names	GNT-IV GnT-IVa GnT-Iva UDP-N-acetylglucosamine:alpha1,3-d-mannosidebeta1,4-N-acetylglucosaminyltransferase EC 2.4.1.145 UDP-GlcNAc:a-1,3-D-mannoside b-1,4-acetylglucosaminyltransferase IV UDP-N-acetylglucosamine: alpha-1,3-D-mannosidebeta-1,4-N-acetylglucosaminyltransferase IVa alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A N-acetylglucosaminyltransferase IVa GlcNAc-T IVa isoenzyme A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase GNT-IVA isozyme A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase

Diseases related to MGAT4A

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Liver Carcinoma
Carcinoma
Diabetes Mellitus, Non-insulin-dependent
Lung Injury
Obesity, Morbid
Malignant Paraganglionic Neoplasm
Malignant Neoplasm Of Liver
Diabetes Mellitus
Insulin Resistance
Malignant Neoplasms
Obesity
Neoplasms
Liver Neoplasms, Experimental
Acute Lung Injury

Pathways for MGAT4A

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Glycosylation
Glucose Homeostasis
Flight
Hemostasis
Secretion
Fucosylation

Research Areas for MGAT4A

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Golgi Apparatus Markers

PTMs for MGAT4A

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Phosphorylation
Glycosylation

Bioinformatics Tool for MGAT4A

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