MEK5 Products

Antibodies
MEK5 Antibody
MEK5 Antibody
NBP1-89655
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
MEK5 Antibody (M1-E6)
MEK5 Antibody (M1-E6)
H00005607-M01
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
MEK5 Antibody (3E10)
MEK5 Antibody (3E10)
H00005607-M11
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Antibody Pairs
MEK5 Antibody Pair
MEK5 Antibody Pair
H00005607-PW1
Species: Hu
Applications: WB, IP
Lysates
MEK5 Overexpression Lysate (D ...
MEK5 Overexpression Lysate (Denatu...
H00005607-T01
Species: Hu
Applications: WB
MEK5 Overexpression Lysate (N ...
MEK5 Overexpression Lysate (Native)
NBP2-05497
Applications: WB
Proteins
MEK5 Recombinant Protein
MEK5 Recombinant Protein
H00005607-P01
Species: Hu
Applications: WB, ELISA, PA
MEK5 Partial Recombinant Prot ...
MEK5 Partial Recombinant Protein
H00005607-Q01
Species: Hu
Applications: WB, ELISA, PA
MEK5 Recombinant Protein Anti ...
MEK5 Recombinant Protein Antigen
NBP1-89655PEP
Species: Hu
Applications: AC
RNAi
MEK5 RNAi
MEK5 RNAi
H00005607-R08
Species: Hu
Applications: RNAi, RNAi SP
MEK5 RNAi
MEK5 RNAi
H00005607-R07
Species: Hu
Applications: RNAi, RNAi SP
MEK5 RNAi
MEK5 RNAi
H00005607-R06
Species: Hu
Applications: RNAi, RNAi SP

Description

Mitogen-acitvated protein kinase kinase 5 (MKK5) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MAPKs require dual phosphorylation on threonine and tyrosine residues, an activation step carried out by MAPK kinase (1-2). The MAPK cascade plays an important role in signaling defense responses. Of the MKK family members, MKK5 exhibits the closest homology to MEK1 and MEK2, with 46% amino acid identity in the catalytic domain (3) MKK has been show to activate extracellular-signal-regulated protein kinase 5 (ERK5). Also, activated ERK5 phosphorylates mitogen- MKK5 extensively at Ser129, Ser137, Ser142 and Ser149, which are located within the region in MKK5 that is thought to interact with ERK5 (3). There have also been findings to that the MEK5 (MKK5)/ERK5 (BMK) pathway may play a role in prostate cancer (5).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Rat
Product By Gene ID 5607
Alternate Names
  • MAPK/ERK kinase 5
  • MKK5
  • MAP kinase kinase 5
  • MAP kinase kinase MEK5b
  • HsT17454
  • PRKMK5dual specificity mitogen-activated protein kinase kinase 5
  • MAPKK5EC 2.7.12.2
  • MEK5MEK 5
  • MAPKK 5
  • mitogen-activated protein kinase kinase 5

Research Areas for MEK5

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Phospho-Specific
Protein Kinase

PTMs for MEK5

Learn more about PTMs related to MEK5.

Phosphorylation
Methylation
Biotinylation
Cleavage
Ubiquitination

Bioinformatics Tool for MEK5

Discover related pathways, diseases and genes to MEK5. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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