MED27 Products

Description

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.

Bioinformatics

Entrez	9442 Human
Uniprot	AAH02878 Human NM_004269 Human NP_004260.2 Human
Product By Gene ID	9442
Alternate Names	cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa CRSP34CRSP complex subunit 8 CRSP8CRAP34 mediator complex subunit 27Transcriptional coactivator CRSP34 mediator of RNA polymerase II transcription subunit 27 MGC11274 P37 TRAP/SMCC/PC2 subunit subunit 8 (34kD) TRAP37