Mark3 Products

Antibodies
Mark3 Antibody
Mark3 Antibody
NBP1-85389
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Mark3 Antibody (2G12)
Mark3 Antibody (2G12)
NBP2-37445
Species: Hu, Mu
Applications: WB, ELISA, Flow, IHC
Host: Mouse Monoclonal
Mark3 Antibody (2G8)
Mark3 Antibody (2G8)
NBP2-45754
Species: Hu
Applications: WB, IHC
Host: Mouse monoclonal
Lysates
Mark3 Overexpression Lysate ( ...
Mark3 Overexpression Lysate (Native)
NBL1-12899
Applications: WB
Mark3 Overexpression Lysate ( ...
Mark3 Overexpression Lysate (Native)
NBP2-09488
Applications: WB
Mark3 Overexpression Lysate ( ...
Mark3 Overexpression Lysate (Denat...
H00004140-T01
Species: Hu
Applications: WB
Proteins
Recombinant Human Mark3 Prote ...
Recombinant Human Mark3 Protein
H00004140-P01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human Mark3 Prote ...
Recombinant Human Mark3 Protein
H00004140-Q01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human Mark3 Prote ...
Recombinant Human Mark3 Protein
H00004140-Q02
Species: Hu
Applications: WB, ELISA, PA
RNAi
Mark3 RNAi
Mark3 RNAi
H00004140-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

MARK3 is a dual-specificity protein kinase that controls entry into mitosis by dephosphorylating Cdc2 on both threonine 14 and tyrosine 15. MARK3 is phosphorylated on serine 216 throughout interphase but not during mitosis. Serine 216 phosphorylation mediates the binding of 14-3-3 protein to MARK3, and MARK3/14-3-3 complexes are present throughout interphase but not during mitosis (1). Kinase suppressor of Ras (KSR) is a conserved component of the Ras pathway that interacts directly with MEK and MAPK. It has been shown that KSR1 translocates from the cytoplasm to the cell surface in response to growth factor treatment and that this process is regulated by MARK3 (2). MARK3 seems to be a positive regulator of the beta-catenin pathway and an inhibitor of the JNK pathway. These findings show that MARK3, a regulator of polarity, is also a modulator of Wnt-beta-catenin signalling, indicating a link between two important developmental pathways (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 4140
Alternate Names
  • C-TAK1
  • EC 2.7.11
  • Serine/threonine-protein kinase p78
  • cTAK1
  • Ser/Thr protein kinase PAR-1
  • EMK2
  • Protein kinase STK10
  • PAR1A
  • Cdc25C-associated protein kinase 1
  • EC 2.7.11.1
  • KP78
  • CTAK1ELKL motif kinase 2
  • EMK-2
  • MAP/microtubule affinity-regulating kinase 3

Research Areas for Mark3

Find related products by research area and learn more about each of the different research areas below.

Protein Kinase

PTMs for Mark3

Learn more about PTMs related to Mark3.

Phosphorylation
Dephosphorylation

Bioinformatics Tool for Mark3

Discover related pathways, diseases and genes to Mark3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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