Mark3 Products

Description

MARK3 is a dual-specificity protein kinase that controls entry into mitosis by dephosphorylating Cdc2 on both threonine 14 and tyrosine 15. MARK3 is phosphorylated on serine 216 throughout interphase but not during mitosis. Serine 216 phosphorylation mediates the binding of 14-3-3 protein to MARK3, and MARK3/14-3-3 complexes are present throughout interphase but not during mitosis (1). Kinase suppressor of Ras (KSR) is a conserved component of the Ras pathway that interacts directly with MEK and MAPK. It has been shown that KSR1 translocates from the cytoplasm to the cell surface in response to growth factor treatment and that this process is regulated by MARK3 (2). MARK3 seems to be a positive regulator of the beta-catenin pathway and an inhibitor of the JNK pathway. These findings show that MARK3, a regulator of polarity, is also a modulator of Wnt-beta-catenin signalling, indicating a link between two important developmental pathways (3).

Bioinformatics

Entrez	4140 Human 17169 Mouse 170577 Rat
Uniprot	P27448 Human P27448-3 Human NP_002367 Human NP_002367.4 Human NP_001122393 Human AAH24773 Human AAH24773.1 Human NM_002376 Human EAW81819.1 Human
Product By Gene ID	4140
Alternate Names	C-TAK1 EC 2.7.11 Serine/threonine-protein kinase p78 cTAK1 Ser/Thr protein kinase PAR-1 EMK2 Protein kinase STK10 PAR1A Cdc25C-associated protein kinase 1 EC 2.7.11.1 KP78 CTAK1ELKL motif kinase 2 EMK-2 MAP/microtubule affinity-regulating kinase 3

Diseases related to Mark3

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Neoplasms
Obesity
Brain Ischemia
Infectious Mononucleosis
Carcinogenesis
Insulin Resistance
Fracture
Malignant Neoplasms
Mammary Neoplasms
Osteoporosis
Cerebral Ischemia
Hypoglycemia
Trematode Infections
Fatty Liver
Germline Mutation Abnormality
Ischemia
Liver Carcinoma

Pathways for Mark3

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Cell Cycle
Mitosis
Localization
Dna Damage Checkpoint
Cell Growth
Interphase
Secretion
Osteoclast Differentiation
Cell Cycle Checkpoint
Insulin Secretion
Hypersensitivity
Gluconeogenesis
Energy Homeostasis
Nuclear Export
Cell Cycle Arrest
Cytokinesis
Cell Death
S Phase
Autophagy

Research Areas for Mark3

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Protein Kinase

PTMs for Mark3

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Phosphorylation
Dephosphorylation

Bioinformatics Tool for Mark3

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