Mark3 Products

Description

MARK3 is a dual-specificity protein kinase that controls entry into mitosis by dephosphorylating Cdc2 on both threonine 14 and tyrosine 15. MARK3 is phosphorylated on serine 216 throughout interphase but not during mitosis. Serine 216 phosphorylation mediates the binding of 14-3-3 protein to MARK3, and MARK3/14-3-3 complexes are present throughout interphase but not during mitosis (1). Kinase suppressor of Ras (KSR) is a conserved component of the Ras pathway that interacts directly with MEK and MAPK. It has been shown that KSR1 translocates from the cytoplasm to the cell surface in response to growth factor treatment and that this process is regulated by MARK3 (2). MARK3 seems to be a positive regulator of the beta-catenin pathway and an inhibitor of the JNK pathway. These findings show that MARK3, a regulator of polarity, is also a modulator of Wnt-beta-catenin signalling, indicating a link between two important developmental pathways (3).

Bioinformatics

Entrez	170577 Rat 17169 Mouse 4140 Human
Uniprot	AAH24773 Human AAH24773.1 Human EAW81819.1 Human NM_002376 Human NP_001122393 Human NP_002367 Human NP_002367.4 Human P27448 Human P27448-3 Human
Product By Gene ID	4140
Alternate Names	Cdc25C-associated protein kinase 1 cTAK1 C-TAK1 CTAK1ELKL motif kinase 2 EC 2.7.11 EC 2.7.11.1 EMK2 EMK-2 KP78 MAP/microtubule affinity-regulating kinase 3 PAR1A Protein kinase STK10 Ser/Thr protein kinase PAR-1 Serine/threonine-protein kinase p78

Research Areas for Mark3

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Protein Kinase