MANEA Products

Description

N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005 [PubMed 15677381]).[supplied by OMIM]

Bioinformatics

Entrez	79694 Human
Uniprot	NP_078917 Human NP_078917.2 Human Q5SRI9 Human
Product By Gene ID	79694
Alternate Names	alpha 1,2-endomannosidase DKFZp686D20120 EC 3.2.1 EC 3.2.1.130 ENDO Endo-alpha mannosidase endomannosidase Endomannosidase FLJ12838 glycoprotein endo-alpha-1,2-mannosidase hEndo Mandaselin mandaselin mannosidase, endo-alpha

Research Areas for MANEA

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism