Species: Hu
Applications: WB, IHC
Host: Mouse monoclonal
Species: Hu
Applications: WB, Flow, IHC
Host: Mouse Monoclonal
Species: Hu, Mu(-)
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Description
LIME (Lck-interacting molecule) is a new raft-associated adaptor protein involved in regulation of T cell activation by coreceptors. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cells results in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation.
Bioinformatics
| Entrez |
Rat
Human
Mouse
|
| Uniprot |
Human
Human
Mouse
|
| Product By Gene ID |
54923 |
| Alternate Names |
- dJ583P15.4
- FLJ20406
- Lck interacting transmembrane adaptor 1
- Lck-interacting membrane protein
- Lck-interacting molecule
- lck-interacting transmembrane adapter 1
- LIMELP8067
|
Research Areas for LIME
Find related products by research area and learn more about each of the different research areas below.
Signal Transduction
