LIME Products

Description

LIME (Lck-interacting molecule) is a new raft-associated adaptor protein involved in regulation of T cell activation by coreceptors. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cells results in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation.

Bioinformatics

Entrez	54923 Human 72699 Mouse 362289 Rat
Uniprot	AAH17016.1 Human NM_017806 Human NP_076173.1 Mouse
Product By Gene ID	54923
Alternate Names	Lck-interacting membrane protein lck-interacting transmembrane adapter 1 dJ583P15.4 FLJ20406 LIMELP8067 Lck-interacting molecule Lck interacting transmembrane adaptor 1

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Signal Transduction

Bioinformatics Tool for LIME

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