LCAT Products

Description

Lecithin-Cholesterol Acyltransferase (LCAT) is the plasma enzyme responsible for most HDL cholesteryl esters in human plasma. In species with cholesteryl ester transfer protein (CETP) it is also responsible for a significant proportion of VLDL and LDL cholesteryl esters. LCAT, through the esterification of cholesterol, plays a role in the reverse cholesterol transport pathway by facilitating the net movement of cholesterol from peripheral tissues back to the liver for excretion. LCAT deficiency results in low levels of plasma HDL, whereas a transgenic overexpression of LCAT results in increased plasma HDL concentrations.

LCAT antibodies are useful tools for lipid and cholesterol metabolism research.

Bioinformatics

Entrez	3931 Human 16816 Mouse
Uniprot	NP_000220.1 Human AAH14781 Human NM_000229 Human P04180 Human
Product By Gene ID	3931
Alternate Names	phosphatidylcholine-sterol acyltransferase EC 2.3.1.43 lecithin-cholesterol acyltransferasePhospholipid-cholesterol acyltransferase

Diseases related to LCAT

Discover more about diseases related to LCAT.

Lecithin Acyltransferase Deficiency
Atherosclerosis
Hyperlipidemia
Arteriosclerosis
Hypolipoproteinemias
Hypercholesterolemia
Coronary Heart Disease
Cardiovascular Diseases
Diabetes Mellitus
Fish-eye Disease
Heart Diseases
Proteinuria Of Undiagnosed Cause
Liver Diseases
Anemia
Coronary Artery Disease
Hyperlipoproteinemias
Kidney Diseases
Kidney Failure, Chronic
Dyslipidemias
Kidney Failure

Pathways for LCAT

View related products by pathway and learn more about each of the pathways below.

Transport
Cholesterol Esterification
Cholesterol Transport
Reverse Cholesterol Transport
Cholesterol Efflux
Secretion
Excretion
Lipid Binding
Pathogenesis
Cholesterol Homeostasis
Glycosylation
Lipid Transport
Localization
Regeneration
Parturition
Lipoprotein Oxidation
Aging
Liver Regeneration
Acute-phase Response
Platelet Aggregation

Research Areas for LCAT

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cholesterol Metabolism
Lipid and Metabolism
Signal Transduction

PTMs for LCAT

Learn more about PTMs related to LCAT.

Oxidation
Glycosylation
Cleavage
Acylation
Reduction
Acetylation
Methylation
Demethylation
Nitration
Biotinylation
Deglycosylation
Iodination

Bioinformatics Tool for LCAT

Discover related pathways, diseases and genes to LCAT. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.