Hu, Mu, RtApplications:
WB, IHC, IHC-PHost:
Applications: WB, ELISA, PA, AP
LATS1 is encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
|Product By Gene ID
- EC 2.7.11
- Large tumor suppressor homolog 1
- serine/threonine-protein kinase LATS1
- LATS (large tumor suppressor, Drosophila) homolog 1
- WARTSEC 18.104.22.168
- WARTS protein kinase
- LATS, large tumor suppressor, homolog 1 (Drosophila)
Bioinformatics Tool for LATS1
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Related LATS1 Blog Posts
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