LATS1 Products

Antibodies
LATS1 Antibody
LATS1 Antibody
NBP1-86860
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
LATS1 Antibody
LATS1 Antibody
NBP1-58271
Species: Hu
Applications: WB, IP
Host: Rabbit Polyclonal
LATS1 Antibody (3A7)
LATS1 Antibody (3A7)
H00009113-M09
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Lysates
LATS1 Overexpression Lysate ( ...
LATS1 Overexpression Lysate (Denat...
H00009113-T02
Species: Hu
Applications: WB
Proteins
Recombinant Human LATS1 Prote ...
Recombinant Human LATS1 Protein
P5573
Species: Hu
Applications: PAGE
Recombinant Human LATS1 Prote ...
Recombinant Human LATS1 Protein
H00009113-Q01
Species: Hu
Applications: WB, ELISA, PA
LATS1 Recombinant Protein Ant ...
LATS1 Recombinant Protein Antigen
NBP1-86860PEP
Species: Hu
Applications: AC
RNAi
LATS1 RNAi
LATS1 RNAi
H00009113-R03
Species: Hu
Applications: RNAi, RNAi SP

Description

LATS1 is encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Product By Gene ID 9113
Alternate Names
  • EC 2.7.11
  • h-warts
  • wts
  • Large tumor suppressor homolog 1
  • serine/threonine-protein kinase LATS1
  • LATS (large tumor suppressor, Drosophila) homolog 1
  • WARTSEC 2.7.11.1
  • WARTS protein kinase
  • LATS, large tumor suppressor, homolog 1 (Drosophila)

Research Areas for LATS1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Cycle and Replication
Mitotic Regulators
Tumor Suppressors

PTMs for LATS1

Learn more about PTMs related to LATS1.

Phosphorylation
Methylation
Ubiquitination
Cleavage
Dephosphorylation
Reduction

Bioinformatics Tool for LATS1

Discover related pathways, diseases and genes to LATS1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related LATS1 Blog Posts

Check out the latest blog posts on LATS1.
TAZ Antibody: The Devil is in the Details
WW domain-containing transcription regulator protein 1 also known as WWTR1 and TAZ, is a 44KDa protein that acts as a downstream regulatory target in the Hippo signaling pathway. This protein undergoes post-translational modification and becomes phosp...    Read more.
Read more LATS1 related blogs.