Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Applications: WB, ELISA, PA, AP
Applications: RNAi, RNAi SP
LATS1 is encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
|Product By Gene ID
- EC 2.7.11
- Large tumor suppressor homolog 1
- serine/threonine-protein kinase LATS1
- LATS (large tumor suppressor, Drosophila) homolog 1
- WARTSEC 18.104.22.168
- WARTS protein kinase
- LATS, large tumor suppressor, homolog 1 (Drosophila)
Bioinformatics Tool for LATS1
Discover related pathways, diseases and genes to LATS1. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.
Related LATS1 Blog Posts
Check out the latest blog posts on LATS1.
Read more LATS1 related blogs.
|TAZ Antibody: The Devil is in the Details
WW domain-containing transcription regulator protein 1 also known as WWTR1 and TAZ, is a 44KDa protein that acts as a downstream regulatory target in the Hippo signaling pathway. This protein undergoes post-translational modification and becomes phosp... Read more.