Latrophilin 1/LPHN1 Products

Antibodies
Latrophilin 1/LPHN1 Antibody
Latrophilin 1/LPHN1 Antibody
NBP1-85609
Species: Hu, Mouse, Rat
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Latrophilin 1/LPHN1 Antibody
Latrophilin 1/LPHN1 Antibody
NLS1126
Species: Hu, Rt, Po, Bt, Bv, Ca, Ha, Mk, Pm, Rb, Opossum
Applications: IHC-P
Host: Rabbit Polyclonal
Latrophilin 1/LPHN1 Antibody
Latrophilin 1/LPHN1 Antibody
H00022859-D01P
Species: Hu
Applications: WB, ELISA
Host: Rabbit Polyclonal
Lysates
Latrophilin 1/LPHN1 Overexpre ...
Latrophilin 1/LPHN1 Overexpression...
H00022859-T04
Applications: WB
Proteins
Latrophilin 1/LPHN1 Partial R ...
Latrophilin 1/LPHN1 Partial Recomb...
H00022859-Q01
Species: Hu
Applications: WB, ELISA, PA
Latrophilin 1/LPHN1 Recombina ...
Latrophilin 1/LPHN1 Recombinant Pr...
H00022859-P01
Species: Hu
Applications: WB, ELISA, PA
Latrophilin 1/LPHN1 Recombina ...
Latrophilin 1/LPHN1 Recombinant Pr...
NBP1-85609PEP
Species: Hu
Applications: AC
RNAi
Latrophilin 1/LPHN1 RNAi
Latrophilin 1/LPHN1 RNAi
H00022859-R03
Species: Hu
Latrophilin 1/LPHN1 RNAi
Latrophilin 1/LPHN1 RNAi
H00022859-R04
Species: Hu

Description

Latrophilin-1 is a brain-specific Orphan-B Receptor that binds alpha-latrotoxin, a potent presynaptic neurotoxin present in the venom of the black widow spider, in a Ca2+-independent manner. As with the other two latrophilins, it shares homology with lectin, olfactomedin, and transmembrane domains, and possesses variable C-termini and various alternative-splicing sites. CIRL is endogenously cleaved into two pieces at the GPCR proteolytic site (GPS) located adjacent to the first transmembrane helix as a mechanism to compartmentalize the cell adhesion and GPCR activation functions. Latrophilin-1 has been reported to be expressed predominantly in the brain. Very weak expression has also been documented in human heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. ESTs have been isolated from brain, eye, kidney, lung, and lymph node libraries. In addition, ESTs have been isolated from the following cancer libraries: brain, choriocarcinoma, epithelioid carcinoma, kidney, and lung.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 22859
Alternate Names
  • Lectomedin-2
  • Calcium-independent alpha-latrotoxin receptor 1
  • lectomedin-2
  • KIAA0821
  • latrophilin-1
  • CIRL1
  • LEC2CL1
  • CIRL-1
  • latrophilin 1

Pathways for Latrophilin 1/LPHN1

View related products by pathway and learn more about each of the pathways below.

Proteolysis
Exocytosis
Cell Adhesion
Regulation Of Exocytosis
Cell Division
Axon Guidance
Embryogenesis And Morphogenesis
Localization

Research Areas for Latrophilin 1/LPHN1

Find related products by research area and learn more about each of the different research areas below.

Cancer
GPCR

PTMs for Latrophilin 1/LPHN1

Learn more about PTMs related to Latrophilin 1/LPHN1.

Cleavage

Bioinformatics Tool for Latrophilin 1/LPHN1

Discover related pathways, diseases and genes to Latrophilin 1/LPHN1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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