Laminin alpha 4 Products

Description

Laminins are essential and abundant structural non-collagenous glycoproteins localizing to basement membranes. Basement membranes (cellassociated extracellular matrices (ECMs)) are polymers of laminins with stabilizing type IV collagen networks, nidogen, and several proteoglycans.Basement membranes are found under epithelial layers, around the endothelium of blood vessels, and surrounding muscle, peripheral nerve, and fat cells. Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression, and tissue architecture. Each laminin is a heterotrimer of alpha, beta, and gamma chain subunits that undergoes cell-secretion and incorporation into the ECM. Laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycan, and cognate laminin receptors. The human laminin alpha-4 gene maps to chromosome 6q21 and is expressed in adult heart, lung, ovary, small and large intestines, liver, and placenta.

Bioinformatics

Entrez	16775 Mouse 3910 Human
Uniprot	AAH04241 Human AAH04241.1 Human Q16363 Human
Product By Gene ID	3910
Alternate Names	DKFZp686D23145 LAMA3LAMA4*-1 laminin alpha 4 chain laminin subunit alpha-4 laminin, alpha 4 Laminin-14 subunit alpha Laminin-8 subunit alpha Laminin-9 subunit alpha