Kv4.2 Products

Antibodies
Lysates
Kv4.2 Overexpression Lysate ( ...
Kv4.2 Overexpression Lysate (Native)
NBP2-10358
Applications: WB
Proteins
Kv4.2 Recombinant Protein Ant ...
Kv4.2 Recombinant Protein Antigen
NBP1-87708PEP
Species: Hu
Applications: AC
RNAi
Kv4.2 RNAi
Kv4.2 RNAi
H00003751-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Kv4.2, a voltage-gated K+ (Kv) channel subunit, has been suggested to be the key component of the subthreshold A-type K+ currents (I(SA)s) recorded from the specific subcellular compartments of certain CNS neurons (1). A-type channels, encoded by the pore-forming alpha-subunits of the Kv4.x family, are particularly important in regulating membrane excitability in the CNS and the heart. Kv4.2 is a Shal-type potassium channel that passes an A-type current and is localized to dendrites and cell bodies in the hippocampus (2). Deletion of the Kv4.2 gene and a loss of Kv4.2 protein resulted in a specific and near-complete elimination of A-type K+ currents from the apical dendrites of CA1 pyramidal neurons. The absence of dendritic Kv4.2-encoded A-type K+ currents led to an increase of bAP amplitude and an increase of concurrent Ca2+ influx (3).

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Rat
Product By Gene ID 3751
Alternate Names
  • RK5
  • voltage-sensitive potassium channel
  • voltage-gated potassium channel Kv4.2
  • potassium voltage-gated channel, Shal-related subfamily, member 2

Research Areas for Kv4.2

Find related products by research area and learn more about each of the different research areas below.

Neuronal Cell Markers
Neuroscience
Neurotransmission

Bioinformatics Tool for Kv4.2

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