Species: Mu
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, Flow, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ELISA, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
Kv4.2, a voltage-gated K+ (Kv) channel subunit, has been suggested to be the key component of the subthreshold A-type K+ currents (I(SA)s) recorded from the specific subcellular compartments of certain CNS neurons (1). A-type channels, encoded by the pore-forming alpha-subunits of the Kv4.x family, are particularly important in regulating membrane excitability in the CNS and the heart. Kv4.2 is a Shal-type potassium channel that passes an A-type current and is localized to dendrites and cell bodies in the hippocampus (2). Deletion of the Kv4.2 gene and a loss of Kv4.2 protein resulted in a specific and near-complete elimination of A-type K+ currents from the apical dendrites of CA1 pyramidal neurons. The absence of dendritic Kv4.2-encoded A-type K+ currents led to an increase of bAP amplitude and an increase of concurrent Ca2+ influx (3).
Bioinformatics
| Entrez |
Human
Rat
|
| Uniprot |
Human
Rat
Human
|
| Product By Gene ID |
3751 |
| Alternate Names |
- potassium voltage-gated channel, Shal-related subfamily, member 2
- RK5
- voltage-gated potassium channel Kv4.2
- voltage-sensitive potassium channel
|
