KIR2DL5/CD158f Products

Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells andsubsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies amonghaplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4,KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and bywhether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduceinhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins withthe short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase bindingprotein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules;thus, KIR proteins are thought to play an important role in regulation of the immune response. (provided by RefSeq)

Bioinformatics

Entrez	57292 Human
Uniprot	AAI60063.1 Human NP_065396 Human
Product By Gene ID	57292
Alternate Names	CD158F CD158F1 killer cell immunoglobulin-like receptor 2DL5A killer cell immunoglobulin-like receptor KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A killer-cell Ig-like receptor KIR2DL5 KIR2DL5.1 KIR2DL5.3 KIR2DL5B