Kif2a Products

Description

The kinesin-related proteins are involved in functions related to movements of organelles, microtubules, or chromosomes along microtubules. These functions include axonal transport, microtubule sliding during nuclear fusion or division, and chromosome disjunction during meiosis and early mitosis. The kinesins are tetramers composed of 2 heavy and 2 light chains. The N-terminal heavy chain sequences show similarity in all the kinesin-related proteins. The N-terminal part forms the motor domain, with the microtubule-binding region allowing the protein to slide along the microtubule. It also possesses an ATP-binding site allowing an ATPase activity that provides the energy required for the movement. Kinesin-like motor proteins are found in several vertebrate cell types but are most strongly expressed in neuronal cells. In dividing cells it is required for bipolar spindle formation and chromosome segregation. In neuronal cells it is involved in neurite outgrowth.

Bioinformatics

Entrez	3796 Human
Uniprot	NP_004511.1 Human
Product By Gene ID	3796
Alternate Names	HK2 KIF2kinesin-2 kinesin heavy chain member 2 kinesin heavy chain member 2A Kinesin, heavy chain, 2 Kinesin-2 kinesin-like protein KIF2A KNS2

Research Areas for Kif2a

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Biology
Cell Cycle and Replication
Cellular Markers
Signal Transduction

Related Kif2a Blog Posts

Check out the latest blog posts on Kif2a.

Kif2a and MT-Destabilization during Mitosis Kif2a belongs to the Kinesin-13 microtubule depolymerase family that includes members Kif2a, Kif2b, and Kif2c. These proteins are capable of depolymerizing microtubules (MTs) at their ends. During mitotic cell division, Kif2a specifically localizes to...    Read more.

Read more Kif2a related blogs.