ITCH/AIP4 Products

Antibodies
ITCH/AIP4 Antibody
ITCH/AIP4 Antibody
NBP1-89180
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
ITCH/AIP4 Antibody
ITCH/AIP4 Antibody
NB100-68142
Species: Hu
Applications: WB, PEP-ELISA
Host: Goat Polyclonal
ITCH/AIP4 Antibody (1B8)
ITCH/AIP4 Antibody (1B8)
H00083737-M06
Species: Hu
Applications: ELISA, ICC/IF
Host: Mouse Monoclonal
Lysates
ITCH/AIP4 Overexpression Lysa ...
ITCH/AIP4 Overexpression Lysate (D...
H00083737-T01
Species: Hu
Applications: WB
ITCH/AIP4 Overexpression Lysa ...
ITCH/AIP4 Overexpression Lysate (N...
NBL1-12057
Applications: WB
Proteins
ITCH/AIP4 Partial Recombinant ...
ITCH/AIP4 Partial Recombinant Protein
H00083737-Q01
Species: Hu
Applications: WB, ELISA, PA
ITCH/AIP4 Recombinant Protein ...
ITCH/AIP4 Recombinant Protein Antigen
NBP1-89180PEP
Species: Hu
Applications: AC
RNAi
ITCH/AIP4 RNAi
ITCH/AIP4 RNAi
H00083737-R01
Species: Hu

Description

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 83737
Alternate Names
  • EC 6.3.2
  • atrophin-1 interacting protein 4
  • Itch
  • AIF4
  • EC 6.3.2.-
  • itchy (mouse homolog) E3 ubiquitin protein ligase
  • ubiquitin protein ligase ITCH
  • NFE2-associated polypeptide 1
  • itchy homolog E3 ubiquitin protein ligase
  • Atrophin-1-interacting protein 4
  • NAPP1E3 ubiquitin-protein ligase Itchy homolog
  • AIP4dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4))
  • dJ468O1.1
  • itchy E3 ubiquitin protein ligase homolog (mouse)

Bioinformatics Tool for ITCH/AIP4

Discover related pathways, diseases and genes to ITCH/AIP4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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