IRX1 Products

Antibodies
IRX1 Antibody
IRX1 Antibody
NBP1-83090
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
IRX1 Antibody (1A11)
IRX1 Antibody (1A11)
H00079192-M04-100ug
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Proteins
IRX1 Partial Recombinant Prot ...
IRX1 Partial Recombinant Protein
H00079192-Q01
Species: Hu
Applications: WB, ELISA, PA
IRX1 Recombinant Protein Anti ...
IRX1 Recombinant Protein Antigen
NBP1-83090PEP
Species: Hu
Applications: AC
RNAi
IRX1 RNAi
IRX1 RNAi
H00079192-R01
Species: Hu

Description

The Iroquois homeobox gene family of transcription factors regulate aspects of embryonic development including anterior/posterior and dorsal/ventral axis patterning in the central nervous system. The Iroquois family are clustered on two loci, IRXA and IRXB, which map to chromosomes 8 and 13 in mice. The IRXA group includes Irx1, Irx2 and Irx4; the IRXB group is comprises Irx3, Irx5 and Irx6. Irx1 and Irx2 are both widely expressed during development in the lung epithelium and also in the ventricular septum. Irx1 and Irx2 also play a role in digit formation (E11.5-E14.5). The Irx gene family members are each expressed in a distinct pattern during mouse heart development. Specifically, Irx1 and Irx2 are expressed in the ventricular septum and Irx3 is expressed in the ventricular trabeculated myocardium. In addition, Irx4 is expressed in the linear heart tube and the AV canal; Irx5 is expressed in the endocardium lining the ventricular and atrial myocardium. Furthermore, the IRX4 gene may modulate cardiac development and function. Although the heart of Irx4- mice appears to develop normally, adult Irx4- mice exhibit cardiomyopathy, including cardiac hypertrophy and decreased contractility.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Product By Gene ID 79192
Alternate Names
  • iroquois-class homeodomain protein IRX-1
  • IRXA1
  • Iroquois homeobox protein 1
  • Homeodomain protein IRXA1
  • IRX-5
  • iroquois homeobox 1

PTMs for IRX1

Learn more about PTMs related to IRX1.

Methylation
Carboxylation

Bioinformatics Tool for IRX1

Discover related pathways, diseases and genes to IRX1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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