IRS2 Products

Antibodies
IRS2 Antibody (676415) [Uncon ...
IRS2 Antibody (676415) [Unconjugated]
MAB6347
Species: Hu
Applications: WB
Host: Mouse Monoclonal
IRS2 Antibody [Unconjugated]
IRS2 Antibody [Unconjugated]
AF6347
Species: Hu
Applications: WB
Host: Sheep Polyclonal
IRS2 Antibody
IRS2 Antibody
NB100-68244
Species: Hu
Applications: ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Lysates
IRS2 Overexpression Lysate (N ...
IRS2 Overexpression Lysate (Native)
NBP2-07957
Applications: WB
Proteins
IRS2 Partial Recombinant Prot ...
IRS2 Partial Recombinant Protein
H00008660-Q01
Species: Hu
Applications: WB, ELISA, PA

Description

Insulin receptor substrates (IRS), the major intracellular substrates of the insulin receptor (IR), are adaptor proteins that transduce signals from the IR to downstream effectors that are important for the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosphorylated on multiple tyrosine residues. Once phosphorylated, IRS proteins bind and activate Grb-2, SHP2 and the PI3-K p85 subunit (2-3). Sequences of IRS-2 and IRS-1 reveal a highly conserved amino terminus containing a pleckstrin-homology domain and a phosphotyrosine-binding domain, and a poorly conserved carboxy terminus containing several tyrosine phosphorylation motifs. IRS-2 is expressed in many cells, including tissues from IRS-1-/- mice, and may be essential for signaling by several receptor systems such as insulin and cytokine (1).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 8660
Alternate Names
  • IRS-2
  • insulin receptor substrate 2

Research Areas for IRS2

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Lipid and Metabolism
Nutrient Sensing in the Brain
Phospho-Specific
Signal Transduction

Bioinformatics Tool for IRS2

Discover related pathways, diseases and genes to IRS2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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