INTS6 Products

Description

The tumor suppressor gene DICE1 is located within a previously reported critical region of loss of heterozygosity on chromosome 13q14.3. Expression of the remaining DICE1 allele is down-regulated in non-small cell lung carcinomas. In IGF-IR transformed Balb/c 3T3, DICE1 substantially suppressed growth in soft agar. These results demonstrate that DICE1 has a growth-suppressing activity and interferes with anchorage-independent growth of IGF-IR transformed tumor cells dependent upon IGF-I signaling.

Bioinformatics

Entrez	26512 Human
Uniprot	NP_001035027 Human NP_036273 Human NP_036273.1 Human
Product By Gene ID	26512
Alternate Names	DBI1 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26 DICE1DBI-1DDX26ADDX26DEAD box protein DKFZp434B105 HDB INT6 Int6 integrator complex subunit 6 Notchl2 Protein DDX26 Protein deleted in cancer 1 RNA helicase HDB

Research Areas for INTS6

Find related products by research area and learn more about each of the different research areas below.

Cancer
Growth and Development
Neuronal Cell Markers
Tumor Suppressors