Inhibin beta A Products

Description

The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.

Bioinformatics

Entrez	16324 Mouse 3624 Human
Uniprot	AAH07858 Human AAH07858.1 Human NM_002192 Human NP_002183.1 Human P08476 Human
Product By Gene ID	3624
Alternate Names	Activin beta-A chain beta A (activin A, activin AB alpha polypeptide) EDF erythroid differentiation factor Erythroid differentiation protein follicle-stimulating hormone-releasing protein FRP FSH-releasing protein inhibin beta A chain inhibin, beta A Inhibin, beta-1

Research Areas for Inhibin beta A

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