INCENP Products

Antibodies
INCENP Antibody (3D2)
INCENP Antibody (3D2)
NBP2-37471
Species: Hu
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
INCENP Antibody
INCENP Antibody
NB100-2286
Species: Hu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal

Description

In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999).[supplied by OMIM]

Bioinformatics

Entrez Human
Uniprot Human
Product By Gene ID 3619
Alternate Names
  • inner centromere protein INCENP
  • MGC111393
  • inner centromere protein
  • inner centromere protein antigens (135kD, 155kD)
  • chromosomal passenger protein
  • FLJ31633
  • binds and activates aurora-B and -C in vivo and in vitro
  • inner centromere protein antigens 135/155kDa

Research Areas for INCENP

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Chromatin Research
DNA Repair
Mitotic Regulators
Protein Kinase

Bioinformatics Tool for INCENP

Discover related pathways, diseases and genes to INCENP. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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