IL-27R alpha/WSX-1/TCCR Products

Description

Upon antigen challenge, T-helper cells differentiate into two functionally distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-g and lymphotoxin-b that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned. It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1. TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-g and Th1-dependent antibody IgG2a. TCCR is predominantly expressed in thymus, spleen, lymph notes and peripheral blood leukocytes.

Bioinformatics

Entrez	50931 Mouse 9466 Human
Uniprot	NP_004834 Human Q6UWB1 Human
Product By Gene ID	9466
Alternate Names	class I cytokine receptor CRL1IL-27R Cytokine receptor-like 1 IL27R IL-27RA IL-27R-alpha interleukin 27 receptor, alpha interleukin-27 receptor subunit alpha TCCRIL-27 receptor subunit alpha T-cell cytokine receptor type 1 Type I T-cell cytokine receptor WSX-1 WSX1IL-27R subunit alpha zcytor1 ZcytoR1

Research Areas for IL-27R alpha/WSX-1/TCCR

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cytokine Research