IL-10R alpha Products

Description

The IL-10 receptor, IL-10R, is a member of the class II subgroup of the cytokine receptor family and exhibits structural similarity to the interferon receptor. IL-10R is expressed in B cells and T helper cells, as well as in LPS-induced mouse fibroblasts. Overall, mouse IL-10R and human IL-10R share 60% sequence identity at the protein level. Stimulation with IL-10 leads to tyrosine phosphorylation of JAK1 and Tyk2, but not JAK2 or JAK3. In addition to its role as an antagonist of IFN-gamma-mediated macrophage activation, IL-10Ralpha transmits differentiation as well as proliferative signals. IL-10R is constitutively expressed on human natural killer (NK) cells and the direct binding of IL-10 potentiates cytokine production by human NK cells.

Bioinformatics

Entrez	16154 Mouse 3587 Human
Uniprot	NM_001558 Human Q13651 Human Q13651.1 Human
Product By Gene ID	3587
Alternate Names	CD210 antigen CDw210a CDW210A HIL-10R IBD28 IL-10 receptor subunit alpha IL-10R subunit 1 IL-10R1 IL-10RA IL10RIL-10R subunit alpha interleukin 10 receptor, alpha interleukin-10 receptor alpha chain Interleukin-10 receptor subunit 1 interleukin-10 receptor subunit alpha