IKK epsilon/IKBKE Products

Description

Nuclear Factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during the activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kB is associated with IkB proteins in the cytoplasm of the cell, which inhibit NF-kB activity. IkB proteins are phosphorylated by an IkB kinase complex consisting of at least three proteins, IKKa, IKKb, and IKKg. Isolated from a cDNA library of LPS-stimulated mouse macrophage cells, a novel molecule in the IKK complex has been recently identified and designated IKKi and/or IKKe. IKKe is required for the activation of NF-kB by mitogens and T cell receptors but not by TNFa or IL-1. LPS increases the IKKe mRNA level in mouse macrophage cell lines. This protein has significant sequence homology with kinase domains of IKKa and IKKb. Overexpression of wild type IKKe in cells phosphorylates Ser32 and Ser36 of IkBa.

Bioinformatics

Entrez	363984 Rat 56489 Mouse 9641 Human
Uniprot	AF241789 Human NM_014002 Human NP_054721 Human Q14164 Human
Product By Gene ID	9641
Alternate Names	EC 2.7.11 EC 2.7.11.10 I-kappa-B kinase epsilon IkBKE IKK-E IKKEMGC125297 IKK-epsilon IKKI IKK-iMGC125295 Inducible I kappa-B kinase inducible IkappaB kinase inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon inhibitor of nuclear factor kappa-B kinase subunit epsilon KIAA0151IKK-related kinase epsilon MGC125294

Research Areas for IKK epsilon/IKBKE

Find related products by research area and learn more about each of the different research areas below.

Cancer
Phospho-Specific
Protein Kinase