Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rb
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
The transcription factor NF-kappa B coordinates the activation of numerous genes in response to pathogens and pro-inflammatory cytokines, and is, therefore, vital in the development of acute and chronic inflammatory diseases. NF-kappa B is activated by cytokine-activated IKB kinases (IKKs); IKK-alpha and IKK-beta isozymes are found in large complexes. Theses large, interleukin-1-inducible IKK complexes have been found to contain a new protein, termed IKK-complex-associated protein (IKAP), which can bind NIK and IKKs and assemble them into an active kinase complex. IKAP is a scaffold protein and a regulator for 3 different kinases involved in pro-inflammatory cytokine signaling.
Bioinformatics
| Entrez |
Human
|
| Product By Gene ID |
8518 |
| Alternate Names |
- DYS
- elongator complex protein 1
- ELP1DKFZp781H1425
- FD
- FLJ12497
- IKAPdysautonomia (Riley-Day syndrome, hereditary sensory autonomic neuropathy typeIII)
- IkappaB kinase complex-associated protein
- IKI3
- IKK complex-associated protein
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinasecomplex-associated protein
- p150
- TOT1
|
