Ikaros/IKZF1 Products

Description

Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs)

Bioinformatics

Product By Gene ID	10320
Alternate Names	DNA-binding protein Ikaros hIk-1 IK1 IK1LyF-1 Ikaros (zinc finger protein) IKAROS family zinc finger 1 (Ikaros) Ikaros family zinc finger protein 1 Ikaros IKAROSLymphoid transcription factor LyF-1 IKZF1 LYF1 LyF-1 LYF1PRO0758 PRO0758 zinc finger protein, subfamily 1A, 1 (Ikaros) ZNFN1A1 ZNFN1A1CLL-associated antigen KW-6

Research Areas for Ikaros/IKZF1

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Innate Immunity