IFN-alpha J1/IFNA7 Products

Description

Interferons (IFN) are a family of cytokines with potent anti-viral, antiproliferative and immunomodulatory properties, classified based on their binding specificity to cell surface receptors (1). Human IFNA2 was originally cloned in the early ‘80s and now more than a dozen closely related IFN alpha subtypes have been identified in both the human and mouse genome, each sharing about 80% amino acid (aa) sequence homology (2-4). Structurally, type I IFNs belong to the class of five helical‑bundle cytokines, with the IFNA subtypes containing 2 conserved disulfide bonds (5). Mature human IFNA7 shares 59% aa sequence identity with mouse IFNA7. The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 (alpha -subunit) and IFNAR2 (beta -subunit) (6, 7). Individual IFNA subtypes are known to display unique efficacies to viral protection, and IFNA7 has been shown to be a strong inducer of IFN-stimulated genes and anti-viral protection (8). Additionally, IFNA7 exhibits moderate anti-viral effects against SARS-CoV-2 (9).

Bioinformatics

Uniprot	P01567.1
Product By Gene ID	3444
Alternate Names	IFNA7 IFN-alpha 7 IFNalpha J1 IFN-alpha J1 interferon alpha-7 interferon alpha-J1 interferon, alpha 7