IDH3A Products

Description

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq]

Bioinformatics

Entrez	114096 Rat 3419 Human 67834 Mouse
Uniprot	AAH21967 Human NM_005530 Human NP_005521 Human NP_005521.1 Human P50213 Human
Product By Gene ID	3419
Alternate Names	EC 1.1.1 EC 1.1.1.41 H-IDH alpha isocitrate dehydrogenase (NAD+) alpha chain isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isocitrate dehydrogenase 3 (NAD+) alpha Isocitric dehydrogenase subunit alpha NAD(+)-specific ICDH subunit alpha NAD(H)-specific isocitrate dehydrogenase alpha subunit NAD+-specific ICDH

Research Areas for IDH3A

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Stem Cell Markers