HUS1 Products

Description

The protein encoded by the HUS1 gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event.

Bioinformatics

Entrez	3364 Human
Uniprot	AAH07013 Human NM_004507 Human NP_004498 Human NP_004498.1 Human
Product By Gene ID	3364
Alternate Names	checkpoint protein HUS1 hHUS1 HUS1 (S. pombe) checkpoint homolog HUS1 checkpoint homolog (S. pombe) hus1+-like protein

Research Areas for HUS1

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication