Huntingtin Products

Antibodies
Huntingtin Antibody
Huntingtin Antibody
NBP1-44266
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC
Host: Rabbit Polyclonal
Huntingtin Antibody
Huntingtin Antibody
NBP1-44265
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC
Host: Rabbit Polyclonal
Proteins
Huntingtin Partial Recombinan ...
Huntingtin Partial Recombinant Pro...
H00003064-Q01
Species: Hu
Applications: WB, ELISA, PA
Huntingtin Recombinant Protei ...
Huntingtin Recombinant Protein Ant...
NBP1-89710PEP
Species: Hu
Applications: AC
Huntingtin Peptide
Huntingtin Peptide
NBP1-96945
Applications: WB, ELISA, IP
RNAi
Huntingtin RNAi
Huntingtin RNAi
H00003064-R01
Species: Hu

Description

Huntingtin protein (Htt) is a 348 kDa protein product of Huntington's disease (HD, IT15) gene. Huntington's disease is a neurodegenerative disorder caused by a mutation on the HD gene, producing a polyglutamin (polyQ) expansion on the N-terminus of Htt. The mutant Htt leads to cytotoxicity in the striatal neuron (1). This cytotoxicity is modulated by proteolytic cleavage with caspases and calpains, producing N-terminal polyQ fragments. A phosphorylation of Htt may also regulate the cleavage and cytotoxicity of mutant Htt (2). The wild-type Htt up-regulates transcription of brain-derived neurotrophic factor (BDNF), a pro-survival factor for striatal neurons. This suggests restoring wild-type Htt level and increasing BDNF expression level can be therapeutic treatment for Huntington's disease (3). Huntingtin is also cleaved by apopain, a cysteine protease product of death-gene for human, suggesting HD might be a disorder of inappropriate apoptosis (4).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Rat
Product By Gene ID 3064
Alternate Names
  • HD protein
  • huntingtin (Huntington disease)
  • IT15HDHuntington disease protein
  • huntingtin

Research Areas for Huntingtin

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Autophagy
Cytoskeleton Markers
Neurodegeneration
Neuronal Cell Markers
Neuroscience
Phospho-Specific

Bioinformatics Tool for Huntingtin

Discover related pathways, diseases and genes to Huntingtin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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