Hrk Products

Antibodies
Hrk Antibody
Hrk Antibody
AF851
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Hrk Antibody
Hrk Antibody
NBP1-76414
Species: Hu, Mu
Applications: WB, ELISA
Host: Rabbit Polyclonal
Hrk Antibody
Hrk Antibody
NBP1-59447
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Lysates
Hrk Overexpression Lysate (Na ...
Hrk Overexpression Lysate (Native)
NBL1-11709
Applications: WB
Proteins
Hrk Peptide
Hrk Peptide
NBP1-76414PEP
Species: Hu
Applications: AC

Description

Apoptosis or programmed cell death is a physiological cellular process characterized by cell shrinkage, membrane blebbing, DNA fragmentation, and release of Cytochrome C from the mitochondria. It is utilized by the organism to get rid of unwanted cells, which is critical for normal development and homeostasis of an organism. Disregulation of normal apoptosis process have been implicated in a variety of diseases, including cancer, autoimmune diseases, viral infections, etc. Programmed cell death occurs through complex cascades of cell signaling in which Bcl-2 family members, among others, play an important role.The Bcl-2 family of proteins regulate apoptosis as well as execute death signals at the mitochondrion. Members of this family include both pro- and anti-apoptotic proteins that hare homology sequences called Bcl-2 Homology domains (BH1-4) which mediate dimmer formation. The BH3 proteins, such as BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region, which is required for their apoptotic function. They may trigger release of death-inducing molecules such as Cytochrome C, Smac, and endonuclease G. Anti-apoptotic family members, including Bcl-2 and Bcl-XL, play inhibitory roles. Bcl-2 family proteins may form homodimers or heterodimers between pro- and anti-apoptotic members, the ratios of which determine the cell fate.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 8739
Alternate Names
  • HARAKIRI
  • BID3
  • harakiri, BCL2-interacting protein (contains only BH3 domain)
  • death protein 5
  • BH3-interacting domain-containing protein 3
  • BCL2-interacting protein
  • Neuronal death protein DP5
  • activator of apoptosis Hrk
  • DP5
  • activator of apoptosis harakiri
  • harakiri, BCL2 interacting protein (contains only BH3 domain)

PTMs for Hrk

Learn more about PTMs related to Hrk.

Phosphorylation
Methylation
Cleavage
Nitration
Ubiquitination

Bioinformatics Tool for Hrk

Discover related pathways, diseases and genes to Hrk. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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