hnRNP-Q Products

Description

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins

Bioinformatics

Entrez	10492 Human 56403 Mouse
Uniprot	AAH32643 Human AAH40844 Human AAH40844.1 Human O60506 Human
Product By Gene ID	10492
Alternate Names	dJ3J17.2 Glycine- and tyrosine-rich RNA-binding protein GRYRBP GRY-RBPNS1-associated protein 1 heterogeneous nuclear ribonucleoprotein Q hnRNP Q hnRNP-Q HNRPQ HNRPQ1 NSAP1FLJ31626 PP68 synaptotagmin binding, cytoplasmic RNA interacting protein Synaptotagmin-binding, cytoplasmic RNA-interacting protein