hnRNP A1 Products

Description

RNA polymerase II trans cripts in the nucleus are in complex with several proteins called heterogeneous nuclear ribonucleoproteins (hnRNPs). These proteins are important in biological activities such as transcription, premRNA processing, cytoplasmic mRNA translation, and turnover. hnRNPs can be isolated either by immunoprecipitation or by sucrose gradient fractionation of cell extracts.2, 4, 5 Isolated hnRNPs consist of protein groups named A to U and many of these protein groups consist of more than one isoform. The major steady-state proteins of the isolated hnRNP complex are A1, A2, B1, B2, C1, and C2, with a range of molecular weight starting with 34 kDa up to 43 kDa.2, 4, 5 hnRNP-A1 is important in pre-mRNA processing and in mRNA export from the nucleus. The protein binds to its RNA target through a consensus RNA-binding site UAGGGU. The protein contains a 38-amino acid domain called M9, which is important for the interaction with the transportin protein and therefore, for its import and export from the nucleus. RanGTP mediates dissociation of hnRNP -A1 from transportin. hnRNP-A1 is ubiquitously expressed with a higher expression in proliferating and/or transformed cells than in differentiated tissues.6

Bioinformatics

Entrez	3178 Human
Uniprot	P09651 Human
Product By Gene ID	3178
Alternate Names	Helix-destabilizing protein heterogeneous nuclear ribonucleoprotein A1 heterogeneous nuclear ribonucleoprotein A1B protein heterogeneous nuclear ribonucleoprotein B2 protein heterogeneous nuclear ribonucleoprotein core protein A1 hnRNP A1 hnRNP core protein A1 hnRNPA1 hnRNP-A1 HNRPA1MGC102835 nuclear ribonucleoprotein particle A1 protein single-strand DNA-binding protein UP1 Single-strand RNA-binding protein

Research Areas for hnRNP A1

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hnRNP A1 - a ribonucleoprotein regulating gene expression at many levels Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is an abundant ubiquitously expressed protein with important roles in the regulation of gene expression. hnRNP A1 is involved in transcription as well as the splicing, trafficking, and translati...    Read more.

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