hnRNP A1 Products

Antibodies
hnRNP A1 Antibody
hnRNP A1 Antibody
NBP1-32161
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
hnRNP A1 Antibody
hnRNP A1 Antibody
NBP1-57121
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
hnRNP A1 Overexpression Lysat ...
hnRNP A1 Overexpression Lysate (Na...
NBL1-11635
Applications: WB
hnRNP A1 Overexpression Lysat ...
hnRNP A1 Overexpression Lysate (Na...
NBP2-06143
Applications: WB
hnRNP A1 Overexpression Lysat ...
hnRNP A1 Overexpression Lysate (De...
H00003178-T05
Species: Hu
Applications: WB
Proteins
hnRNP A1 Recombinant Protein ...
hnRNP A1 Recombinant Protein Antigen
NBP2-14096PEP
Species: Hu
Applications: AC
hnRNP A1 Recombinant Protein
hnRNP A1 Recombinant Protein
NBP1-99106
Species: Hu
Applications: PAGE
RNAi
hnRNP A1 RNAi
hnRNP A1 RNAi
H00003178-R02
Species: Hu
Applications: RNAi, RNAi SP
hnRNP A1 RNAi
hnRNP A1 RNAi
H00003178-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

RNA polymerase II transcripts in the nucleus are in complex with several proteins called heterogeneous nuclear ribonucleoproteins (hnRNPs). These proteins are important in biological activities such as transcription, pre-mRNA processing, cytoplasmic mRNA translation and turnover. hnRNPs can be isolated either by immunoprecipitation or by sucrose gradient fractionation of cell extracts.1, 3, 4 Isolated hnRNPs consist of protein groups named A to U and many of these protein groups consist of more than one isoform. The major steady-state proteins of the isolated hnRNP complex are A1, A2, B1, B2, C1, and C2, with a range of molecular weight starting with 34 kDa up to 43 kDa.1, 3, 4 hnRNP-A1 is important in pre-mRNA processing and in mRNA export from the nucleus. The protein binds to its RNA target through a consensus RNA-binding site UAGGGU. The protein contains a 38-amino acid domain called M9, which is important for the interaction with the transportin protein, and therefore, for its import and export from the nucleus. RanGTP mediates dissociation of hnRNP-A1 from transportin. hnRNP-A1 is ubiquitously expressed with a higher expression in proliferating and/or transformed cells than in differentiated tissues.5

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 3178
Alternate Names
  • single-strand DNA-binding protein UP1
  • hnRNP core protein A1
  • nuclear ribonucleoprotein particle A1 protein
  • hnRNP A1
  • heterogeneous nuclear ribonucleoprotein core protein A1
  • Single-strand RNA-binding protein
  • heterogeneous nuclear ribonucleoprotein B2 protein
  • Helix-destabilizing protein
  • heterogeneous nuclear ribonucleoprotein A1B protein
  • hnRNP-A1
  • HNRPA1MGC102835
  • hnRNPA1
  • heterogeneous nuclear ribonucleoprotein A1

Research Areas for hnRNP A1

Find related products by research area and learn more about each of the different research areas below.

Core ESC-Like Genes
Stem Cell Markers

PTMs for hnRNP A1

Learn more about PTMs related to hnRNP A1.

Phosphorylation
Methylation
Cleavage
Biotinylation
Deiodination

Bioinformatics Tool for hnRNP A1

Discover related pathways, diseases and genes to hnRNP A1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related hnRNP A1 Blog Posts

Check out the latest blog posts on hnRNP A1.
hnRNP A1 - a ribonucleoprotein regulating gene expression at many levels
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is an abundant ubiquitously expressed protein with important roles in the regulation of gene expression. hnRNP A1 is involved in transcription as well as the splicing, trafficking, and translati...    Read more.
Read more hnRNP A1 related blogs.