HLA-E Products

Description

HLA-E is a class I histocompatibility antigen involved in immune self-nonself discrimination. HLA-E classically binds epitopes from HLA-A, HLA-B, HLA-C and HLA-G signal peptides and serves as a ligand for CD94/NKG2A and CD94/NKG2C receptors on NK and t-cell subsets.  HLA-E down-regulates NK cell cytolytic activity when presented on the cell surface.  It can also restrict non-canonical CD8+ T cells during natural infection with pathogens. HLA-E protein expression in normal human nonlymphoid organs is restricted to endothelial cells.  It is also basally expressed by B and T-lymphocytes, NK cells and macrophages.  TNF-alpha, IL-1beta and IFN-gamma up-regulated cell-surface expression of HLA-EE.

Bioinformatics

Uniprot	P13747 Human
Product By Gene ID	3133
Alternate Names	DKFZp686P19218 EA1.2 EA2.1 HLA class I histocompatibility antigen, alpha chain E HLA class I histocompatibility antigen, E alpha chain HLA-6.2 HLAE HLA-E lymphocyte antigen major histocompatibility complex, class I, E MHC class I antigen E MHC HLA-E alpha-1 MHC HLA-E alpha-2.1 MHC QA1