HLA DRB4 Products

Antibodies
HLA DRB4 Antibody (4C8)
HLA DRB4 Antibody (4C8)
H00003126-M01
Species: Hu
Applications: WB, ELISA, IHC-P
Host: Mouse Monoclonal
HLA DRB4 Antibody
HLA DRB4 Antibody
H00003126-B01P
Species: Hu
Applications: WB
Host: Mouse Polyclonal
HLA DRB4 Antibody
HLA DRB4 Antibody
NBP1-32553
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Lysates
HLA DRB4 Overexpression Lysat ...
HLA DRB4 Overexpression Lysate (Na...
NBL1-11587
Applications: WB
HLA DRB4 Overexpression Lysat ...
HLA DRB4 Overexpression Lysate (De...
H00003126-T01
Species: Hu
Applications: WB
Proteins
Recombinant Human HLA DRB4 Pr ...
Recombinant Human HLA DRB4 Protein
H00003126-P01
Species: Hu
Applications: WB, ELISA, PA
RNAi
HLA DRB4 RNAi
HLA DRB4 RNAi
H00003126-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 3126
Alternate Names
  • MHC HLA DR-beta chain
  • HLA class II histocompatibility antigen, DRB1-12 beta chain
  • MHC class2 antigen
  • HLA class II histocompatibility antigen, DR beta 4 chain
  • MHC class II HLA-DR-beta-7
  • DRB1 transplantation antigen
  • MHC class II antigen HLA-DRB1
  • class II histocompatibility antigen HLA DR alpha, beta1-0307
  • MHC class II antigen HLA-DR-beta
  • HLA-DR4B
  • MHC class II antigen DRB1*4
  • DRB4
  • MHC class II antigen DRB1*14
  • DR4
  • MHC class II antigen DRB1*13
  • DR14
  • MHC class II antigen DRB1*12
  • DR13
  • MHC class I antigen DRB1*4
  • DR12
  • MHC class I antigen DRB1*12
  • DR-4
  • major histocompatibility complex, class II, DR beta 1
  • DR-14
  • leukocyte antigen
  • DR-13
  • leucocyte antigen DRB1
  • DR-12
  • human leucocyte antigen DRB4
  • MHC class II antigen DRB4
  • HLA class II histocompatibility antigen, DRB1-4 beta chain
  • major histocompatibility complex, class II, DR beta 4

Pathways for HLA DRB4

View related products by pathway and learn more about each of the pathways below.

Immune Response
Pathogenesis
Sensitization
Donor Selection

Research Areas for HLA DRB4

Find related products by research area and learn more about each of the different research areas below.

Asthma
Immunology

PTMs for HLA DRB4

Learn more about PTMs related to HLA DRB4.

Citrullination

Bioinformatics Tool for HLA DRB4

Discover related pathways, diseases and genes to HLA DRB4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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