HLA DRB4 Products

Antibodies
HLA DRB4 Antibody
HLA DRB4 Antibody
H00003126-B01P
Species: Hu
Applications: WB
Host: Mouse Polyclonal
HLA DRB4 Antibody
HLA DRB4 Antibody
NBP3-03662
Species: Hu, Mu
Applications: WB
Host: Rabbit Polyclonal
HLA DRB4 Antibody
HLA DRB4 Antibody
NBP1-32553
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Lysates
HLA DRB4 Overexpression Lysat ...
HLA DRB4 Overexpression Lysate
NBL1-11587
Species: Hu
Applications: WB
Proteins
Recombinant Human HLA DRB4 GS ...
Recombinant Human HLA DRB4 GST (N-...
H00003126-P01
Species: Hu
Applications: WB, ELISA, PA, AP

Description

HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 3126
Alternate Names
  • class II histocompatibility antigen HLA DR alpha, beta1-0307
  • DR12
  • DR-12
  • DR13
  • DR-13
  • DR14
  • DR-14
  • DR4
  • DR-4
  • DRB1 transplantation antigen
  • DRB4
  • HLA class II histocompatibility antigen, DR beta 4 chain
  • HLA class II histocompatibility antigen, DRB1-12 beta chain
  • HLA class II histocompatibility antigen, DRB1-4 beta chain
  • HLA-DR4B
  • human leucocyte antigen DRB4
  • leucocyte antigen DRB1
  • leukocyte antigen
  • major histocompatibility complex, class II, DR beta 1
  • major histocompatibility complex, class II, DR beta 4
  • MHC class I antigen DRB1*12
  • MHC class I antigen DRB1*4
  • MHC class II antigen DRB1*12
  • MHC class II antigen DRB1*13
  • MHC class II antigen DRB1*14
  • MHC class II antigen DRB1*4
  • MHC class II antigen DRB4
  • MHC class II antigen HLA-DRB1
  • MHC class II antigen HLA-DR-beta
  • MHC class II HLA-DR-beta-7
  • MHC class2 antigen
  • MHC HLA DR-beta chain

Pathways for HLA DRB4

View related products by pathway and learn more about each of the pathways below.

Immune Response
Pathogenesis
Sensitization
Donor Selection

Research Areas for HLA DRB4

Find related products by research area and learn more about each of the different research areas below.

Asthma
Immunology

PTMs for HLA DRB4

Learn more about PTMs related to HLA DRB4.

Citrullination

Bioinformatics Tool for HLA DRB4

Discover related pathways, diseases and genes to HLA DRB4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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