HLA DQA2 Products

Description

The HLA-DQA2 gene encodes a 255 amino acid long, 28 kDA HLA class II histocompatibility antigen, DQ alpha 2 chain that functions in the peptide loading of MHC class II molecules. It does so by releasing the CLIP molecule from the peptide binding site. The HLA-DQA2 gene participates in cell adhesion molecules (CAMs), antigen processing and presentation, transport of MHC II:Ii complex along Golgi to TGN, the CDC42 pathway, and in G-protein signaling in N-RAS regulation pathways. It is known to interact with genes CD4 and HLA-DQB1. HLA-DQA2 is linked to osteoarthritis, celiac disease, diabetes, asthma, thyroiditis, childhood type dermatomyositis, graft vs. host disease, narcolepsy, and lupus.

Bioinformatics

Product By Gene ID	3118
Alternate Names	DX alpha chain DX-ALPHA HLA class II histocompatibility antigen, DQ alpha 2 chain HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA1 HLA-DXAMHC class II DQA2 major histocompatibility complex, class II, DQ alpha 2