HLA DOB Products

Description

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq]

Bioinformatics

Entrez	3112 Human
Uniprot	NM_002120 Human NP_002111 Human NP_002111.1 Human
Product By Gene ID	3112
Alternate Names	HLA class II histocompatibility antigen, DO beta chain FLJ57033 DOB MHC class II antigen DOB major histocompatibility complex, class II, DO beta

Diseases related to HLA DOB

Discover more about diseases related to HLA DOB.

Dysequilibrium Syndrome
Graves Disease
Autoimmune Diseases
Diabetes Mellitus
Arthritis
Autoimmune Reaction
Malignant Neoplasms
Diabetes Mellitus, Insulin-dependent
Leukemia
Lupus Erythematosus, Systemic
Leukemia, B-cell
Lymphoid Leukemia
Rheumatoid Arthritis
Chronic Lymphocytic Leukemia
Celiac Disease

Pathways for HLA DOB

View related products by pathway and learn more about each of the pathways below.

Transport
Intracellular Transport

Research Areas for HLA DOB

Find related products by research area and learn more about each of the different research areas below.

Asthma
Immunology

Bioinformatics Tool for HLA DOB

Discover related pathways, diseases and genes to HLA DOB. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.