Species: Hu, Mu, Rt, Ca, Ch, Dr, Ma, Ze
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, DB, ELISA
Host: Mouse Monoclonal
Species: Hu
Applications: AC
Description
Changes in chromatin structure play a large role in the regulation of transcription in eukaryotes (1). The nucleosome is the primary building block of chromatin, and is made up of four core histone proteins (H2A, H2B, H3 and H4) (2). Acetylation of core histones regulates gene expression (2). Histone H2B is primarily acetylated at lysines 5, 12, 15, and 20 (3). Ubiquitylation of Histone H2B at lysine 123 by Rad6 has been implicated in transcriptional activation and lysine methylation on histone H3 (4). Histone H2B phosphorylation at Ser10 (for yeast) and Ser14 (for mammalian cells) has been linked to regulation of apoptosis and meiosis (5).
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
|
| Product By Gene ID |
54145 |
| Alternate Names |
- H2B histone family S member10H2B/s
- H2B histone family, member S
- Histone H2B.s
|
![Western Blot Histone H2B, member S [p Ser14] Antibody (C.15200186) - BSA Free](http://images.novusbio.com/fullsize/Histone-H2B-member-S-p-Ser14-Antibody-C-15200186-Western-Blot-NBP2-62794-img0004.jpg)
![Dot Blot Histone H2B, member S [p Ser14] Antibody (C.15200186) - BSA Free](http://images.novusbio.com/fullsize/Histone-H2B-member-S-p-Ser14-Antibody-C-15200186-Dot-Blot-NBP2-62794-img0003.jpg)
![ELISA Histone H2B, member S [p Ser14] Antibody (C.15200186) - BSA Free](http://images.novusbio.com/fullsize/Histone-H2B-member-S-p-Ser14-Antibody-C-15200186-ELISA-NBP2-62794-img0002.jpg)
