HIST3H3 Products


Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber as they play a critical role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. The HIST3H3 gene is intronless and encodes a 136 amino acid long, 15 kDA histone H3.1t protein that lacks polyA tails and obtain a palindromic termination element. The HIST3H3 gene is located separately from the other H3 genes on the cluster on chromosome 6p22-p21.3. HIST3H3 participates in PKA signaling, development notch signaling pathway, histone modification, and interferon pathway through interactions with genes HIST1H4B, HIST4H4, HIST1H4A, HIST1H4C, and HIST1H4D. HIST3H3 has been researched regarding its role in immunodeficiency, leukemia, prostatitis, huntington's disease, lupus, multiple sclerosis, laryngeal cancer, and lymphomas.


Entrez Human
Uniprot Human
Product By Gene ID 8290
Alternate Names
  • H3T
  • histone 3, H3
  • histone H3.1t
  • H3 histone family, member T
  • H3FTMGC126888
  • H3tMGC126886
  • H3/gH3.4
  • H3/t
  • histone cluster 3, H3

Diseases related to HIST3H3

Discover more about diseases related to HIST3H3.

Malignant Neoplasms
Metaplastic Cell Transformation
Malignant Tumor Of Cervix

Pathways for HIST3H3

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Rna Surveillance
Immune Response

Research Areas for HIST3H3

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Chromatin Research
Histones and Modified Histones

Bioinformatics Tool for HIST3H3

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