Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Description
Hepatic sinusoidal endothelial cells (HSEC) plays a key role in various hepatic pathophysiological conditions and are known for their morphological uniqueness - numerous open fenestrations clustered in groups (sieve plates), lack of distinct basal lamina, and abundant vacuolar/vesicular structures. HSECs are distinct from vascular endothelial cells functionally/morphologically and besides providing sinusoidal barrier, they implicates in the balance or distribution of lipids, cholesterol, and vitamin A, and in the uptake of various substances via their specialized endocytotic mechanisms. SE-1 monoclonal antibody has been specifically designed to recognize an antigen expressed in HSEC, but not in other cell types including vascular endothelial cells. Experiments on developing liver have revealed that the expression of SE-1 antigen is possibly regulated via intimate association of HSECs with hepatocytes. Hepatic sinusoidal endothelial cells (SE-1) antibody has been extensively used as one of the most reliable markers for rat HSEC by Western blot and immunohistochemistry analysis and is a useful tool for studying the role of HSE in various hepato-pathophysiological conditions.
Bioinformatics
| Alternate Names |
- Hepatic cells
- Hepatic Sinusoidal Endothelial Cells
- HSE
- SE1
- Sinusoidal Endothelial Cells
|
Research Areas for Hepatic Sinusoidal Endothelial Cells
Find related products by research area and learn more about each of the different research areas below.
Endothelial Cell Markers
