HCN1 Products

HCN1 Antibody (S70-28)
HCN1 Antibody (S70-28)
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-Fr, IHC-P, IP
Host: Mouse Monoclonal
HCN1 Antibody
HCN1 Antibody
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Sheep Polyclonal
HCN1 Antibody
HCN1 Antibody
Species: Hu, Mouse
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
HCN1 Recombinant Protein Anti ...
HCN1 Recombinant Protein Antigen
Species: Hu
Applications: B/N, Ctrl
Species: Hu


Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, play a crucial role in the regulations of cell excitability. Importantly, they contribute to spontaneous rhythmic activity in both the heart and brain (3).


Entrez Human
Uniprot Human
Product By Gene ID 348980
Alternate Names
  • Brain cyclic nucleotide-gated channel 1
  • potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
  • HAC-2
  • BCNG-1brain cyclic nucleotide gated channel 1
  • BCNG1
  • hyperpolarization activated cyclic nucleotide-gated potassium channel 1

PTMs for HCN1

Learn more about PTMs related to HCN1.


Bioinformatics Tool for HCN1

Discover related pathways, diseases and genes to HCN1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related HCN1 Blog Posts

Check out the latest blog posts on HCN1.
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The sense of taste involves the reaction of chemicals with nerve cells which send messages to the brain to create the perception of flavor. Learn more about taste and in the infographic below.Novus Biologicals offers research reagents mentioned in...    Read more.
Read more HCN1 related blogs.